R/O - Avascular necrosis, fractures, infection Flashcards Preview

Year 2 Specialty Medicine > R/O - Avascular necrosis, fractures, infection > Flashcards

Flashcards in R/O - Avascular necrosis, fractures, infection Deck (45):
1

where does ewings sarcoma occur in bone ?

diaphysis

2

where does chondrosarcoma occur in bone?

- pelvis
- vertebral bodies
- metaphysis

3

where does osteosarcoma occur in bone?

physis

4

where do giant cell tumors occur in bone?

epiphysis

5

where in the body do osteomas usually occur?

cortical bones of skull and face

6

which is larger - osteoid osteoma or osteoblastoma?

osteoblastoma

7

which is relieved by aspirin - osteoid osteoma or osteoblastoma?

osteoid osteoma

8

which are painful - osteoid osteoma or osteoblastoma or both?

both

9

osteoblastomas occur in the _________

vertebral column

10

what is the histological appearance of osteoblastomas and osteoid osteomas?

interlacing trabeculae of woven bone surrounded by osteoblasts, loose CT tissue stroma (no marrow elements), may see giant cells

11

osteosarcomas are mesenchymal tumors that produce _________

osteoid

12

what is the most common primary malignant tumor of bone?

osteosarcoma

13

in order to diagnose osteosarcoma, you MUST observe ___________

osteoid

14

osteosarcomas usually arise in what region of the bone?

metaphysis of long bones of the extremities

15

what is the pathophysiology of osteosarcoma?

destroys cortex

- extends inward into marrow cavity
- extends outward to adjacent soft tissues

16

does osteosarcoma produce lytic, blastic, or both types of lesions?

both

17

codman triangle is seen in what bone tumor?

osteosarcoma

18

what is the XR appearance of osteochondroma?

polypoid growth (mushroom)

19

in which part of the bone do osteochondromas usually arise?

metaphysis, near epiphyseal plate

20

chondromas are benign tumors of ________ cartilage

hyaline

21

ENchondromas are chondromas that are confined to what cavity?

medullary cavity

22

where in the body are enchondromas usually found? which part of the bone?

- hands and feet (Ollier disease)
- metaphysis

23

what is the XR appearance of chondromas?

well defined with stippled calcium

24

where in the body do chondrosarcomas arise?

- pelvic bones
- axial skeleton

25

prognosis of chondrosarcomas depends on what pathologic tumor feature?

grade

26

ewing sarcoma tumors are derived from what precursor cell?

multipotent mesenchymal stem cell

27

where in the body do ewing sarcomas arise?

diaphysis

28

ewing sarcomas are __________ (differentiated / undifferentiated), whereas primitive neuroectodermal tumors (PNETs) are ______________ (differentiated / undifferentiated)

- ewing: undifferentiated
- PNET: neural differentiated

29

which displays homer rosette histology - ewing sarcoma or PNET?

PNET

30

what is the translocation seen in ewings sarcoma?

t(11, 22)(q24, q12)

31

ewings sarcomas stain positive for what markers?

- PAS
- CD99

32

histology: sheets of uniform, undifferentiated small round "blue" cells

ewings sarcoma

33

histology: cells form prominent home wright rosettes with central fibrillary cores

PNET

34

fibrous cortical defects occur in what part of the bone?

metaphysis

35

what types of cells are seen histologically in fibrous cortical defects?

multinucleated giant cells and fibroblasts

36

histology: curvilinear spicules of immature woven bone ("Chinese characters")

fibrous dysplasia

37

fibrous dysplasia occurs in what part of the bone?

diaphysis

38

giant cell tumors of bone are aka:

osteoclastoma

39

giant cell tumors of bone (osteoclastomas) arise in what part of the bone and body?

epiphyses of long bones around knee, proximal humerus, distal radius

40

what are the benign and malignant tumors for cell origin type: bone cell

- benign: osteoma, osteoid osteoma
- malignant: osteosarcoma

41

what are the benign and malignant tumors for cell origin type: cartilage

- benign: chondroma
- malignant: chondrosarcoma

42

what are the benign and malignant tumors for cell origin type: osteoblasts

- benign: giant cell tumors (90%)
- malignant: giant cell tumors (10%)

43

what are the benign and malignant tumors for cell origin type: fibroblasts?

- benign: fibrous dysplasia / fibroma
- malignant: fibrosarcoma

44

which is more common - metastatic tumors to bone or primary?

metastatic (20x)

45

most metastatic bone lesions are _____________ (lytic / blastic)

osteolytic