Flashcards in R/O - Avascular necrosis, fractures, infection Deck (45):
where does ewings sarcoma occur in bone ?
where does chondrosarcoma occur in bone?
- vertebral bodies
where does osteosarcoma occur in bone?
where do giant cell tumors occur in bone?
where in the body do osteomas usually occur?
cortical bones of skull and face
which is larger - osteoid osteoma or osteoblastoma?
which is relieved by aspirin - osteoid osteoma or osteoblastoma?
which are painful - osteoid osteoma or osteoblastoma or both?
osteoblastomas occur in the _________
what is the histological appearance of osteoblastomas and osteoid osteomas?
interlacing trabeculae of woven bone surrounded by osteoblasts, loose CT tissue stroma (no marrow elements), may see giant cells
osteosarcomas are mesenchymal tumors that produce _________
what is the most common primary malignant tumor of bone?
in order to diagnose osteosarcoma, you MUST observe ___________
osteosarcomas usually arise in what region of the bone?
metaphysis of long bones of the extremities
what is the pathophysiology of osteosarcoma?
- extends inward into marrow cavity
- extends outward to adjacent soft tissues
does osteosarcoma produce lytic, blastic, or both types of lesions?
codman triangle is seen in what bone tumor?
what is the XR appearance of osteochondroma?
polypoid growth (mushroom)
in which part of the bone do osteochondromas usually arise?
metaphysis, near epiphyseal plate
chondromas are benign tumors of ________ cartilage
ENchondromas are chondromas that are confined to what cavity?
where in the body are enchondromas usually found? which part of the bone?
- hands and feet (Ollier disease)
what is the XR appearance of chondromas?
well defined with stippled calcium
where in the body do chondrosarcomas arise?
- pelvic bones
- axial skeleton
prognosis of chondrosarcomas depends on what pathologic tumor feature?
ewing sarcoma tumors are derived from what precursor cell?
multipotent mesenchymal stem cell
where in the body do ewing sarcomas arise?
ewing sarcomas are __________ (differentiated / undifferentiated), whereas primitive neuroectodermal tumors (PNETs) are ______________ (differentiated / undifferentiated)
- ewing: undifferentiated
- PNET: neural differentiated
which displays homer rosette histology - ewing sarcoma or PNET?
what is the translocation seen in ewings sarcoma?
t(11, 22)(q24, q12)
ewings sarcomas stain positive for what markers?
histology: sheets of uniform, undifferentiated small round "blue" cells
histology: cells form prominent home wright rosettes with central fibrillary cores
fibrous cortical defects occur in what part of the bone?
what types of cells are seen histologically in fibrous cortical defects?
multinucleated giant cells and fibroblasts
histology: curvilinear spicules of immature woven bone ("Chinese characters")
fibrous dysplasia occurs in what part of the bone?
giant cell tumors of bone are aka:
giant cell tumors of bone (osteoclastomas) arise in what part of the bone and body?
epiphyses of long bones around knee, proximal humerus, distal radius
what are the benign and malignant tumors for cell origin type: bone cell
- benign: osteoma, osteoid osteoma
- malignant: osteosarcoma
what are the benign and malignant tumors for cell origin type: cartilage
- benign: chondroma
- malignant: chondrosarcoma
what are the benign and malignant tumors for cell origin type: osteoblasts
- benign: giant cell tumors (90%)
- malignant: giant cell tumors (10%)
what are the benign and malignant tumors for cell origin type: fibroblasts?
- benign: fibrous dysplasia / fibroma
- malignant: fibrosarcoma
which is more common - metastatic tumors to bone or primary?