S3L3: Peripheral and Central Sensitization Flashcards
Increase or Decrease
In peripheral sensitization, afferent nociceptive input is increased through a
1. [] threshold
2. [] responsiveness
3. [] receptive field
increase both responsiveness and receptive field
decrease threshold
T/F
Inflammatory mediators in peripheral sensitization include cytokines, prostaglandins, serotonin
True
T/F
In peripheral sensitization, injury sensitizes the nerve through either inflammation within the neural connective tissue or indirect compromise of the axons
False
Injury sensitizes the nerve through either inflammation within the neural connective tissue or** direct compromise **of the axons
Modified T/F
A. In central sensitization, inflammation in the CNS causes ↑ sensitization by increasing excitability in the ventral horn
B. Processes result in hyperalgesia, allodynia, after sensations,
summation
FT
Inflammation in the CNS causes ↑ sensitization by
increasing excitability in the dorsal horn
Modified T/F
A. Central sensitizaion provides a physiologic explanation for pain in the absence of identifiable injury
B. Peripheral sensitization is the physical mechanism for pain during stress or psyche
TF
Both refers to Central sensitization
T/F
Central sensitization can be maintained by ongoing nociceptive input or be independent of nociceptive input
True
Which of the following brain regions is NOT associated with central sensitization?
A) Spinal Cord (SC)
B) Rostroventral Medulla (RVM)
C) Amygdala
D) Anterior Cingulate Cortex
E) Thalamus
E) Thalamus
Can occur in the SC, RVM, amygdala, anterior cingulate cortex, &** trigeminal brainstem complex**
Modified T/F
A. Wind-Up refers to repeated high-frequency nociceptor stimulation
results in progressively increased action potential in the dorsal horn cells
B. It can cause long-term potentiation
FT
Repeated low-frequency nociceptor stimulation results in progressively increased action potential inthe dorsal horn cells
Which of the following conditions is NOT commonly associated with the occurrence of central sensitization?
A) Fibromyalgia
B) Widespread myofascial pain
C) Chronic headache
D) TMJ disorders
E) Neuropathic pain
F) None of the above
F) None of the above
Identification
Occurs when the pain fiber synapses with the seconday neuron in the dorsal horn is amplified, resulting in the firing of the secondary neuron with lower peripheral
stimulus
Hyperalgesia
Identification
Decreased firing threshold or decreased inhibition
Short-term allodynia
Identification
Includes sprouting of A Alpha and Beta fibers to synapse with nociceptor fibers causing sensory input to be pain
Long-term allodynia
Identify the physiological axis that, when activated by physical or emotional stress, triggers a cascade of events leading to chronic sympathetic activation of chronic pain.
Hypothalamic-Pituitary-Adrenal Axis
Which mechanism contributes to the direct activation of the Spinal Cord by the Autonomic Nervous System, especially when sympathetic efferents connect to deep somatic afferents?
A) Sympathetic efferents stimulating parasympathetic activity
B) Sympathetic afferents sprouting synapses with nociceptors
C) Parasympathetic activation of the dorsal root ganglia
D) Sympathetic inhibition of nociceptive signals
B) Sympathetic afferents sprouting synapses with nociceptors
