Test 4 - Osteoporosis Medications (Josh)

Question 1

Bisphosponates end in what?

Answer 1

-dronate

alenDRONATE
ibanDRONATE
riseDRONATE

Question 2

When taking PO bisphosphantes, what should we teach client?

Answer 2

• Take in AM
• Take on EMPTY STOMACH
• FULL glass of water
• Stay UPRIGHT for 30-60 mins

Question 3

Why does client need to keep standing for 30-60 mins after taking a -dronate?

Answer 3

it is extremely irritating to the esophagus and we don’t want any reflux

Question 4

A/E of -dronate

Answer 4

• Heartburn
• Abdominal Pain
• Diarrhea
• Hypocalcemia
• Osteonoecrosis of the Jaw (ONJ)

Question 5

Benefits of raloxifene (besides increasing bone density).

Answer 5

Decreases cancer risk

Question 6

BBW for raloxifene

Answer 6

Thromboembolism

Stroke

Question 7

How can client minimize risk of Thromboembolism or Stroke while taking raloxifine?

Answer 7

Avoid prolonged inactivity, as can happen when traveling

Patients should discontinue raloxifene at least 72 hours before prolonged immobilization (ie: surgery)

Question 8

—– chew up bones

—– build up bones.

Answer 8

osteoclasts

osteoblasts

Question 9

What is our goal when treating osteoporosis?

Answer 9

We want to block the osteoclasts (that chew up bones)

Question 10

What are the Osteoporosis meds we discussed?

Answer 10

• Bisphosphonates (-dronate)

- Raloxifene

Question 11

Which routes are -dronate given?

Answer 11

PO

IV

Question 12

Why do -dronate cause Hypocalcemia?

Answer 12

They pack the calcium back into the bones, leading to low calcium in the blood

Question 13

Why drink a full glass of water w/ -dronate

Answer 13

So it won’t get stuck in esophagus

Remember it’s EXTREMELY IRRITATING to the esophagus

Question 14

MOA: raloxifene

Answer 14

• mimics estrogen in the bones

- blocks estrogen in breasts & uterus

Question 15

A/E of raloxifene

Answer 15

• Hot Flashes
• Leg Cramping
• Edema (weight gain)