Which bacteria only targets anaerobic bacteria?
Which drug works like a Trojan horse? What is it similar to in this regard?
Similar to nitrofurantoin (UTI drug)
Once it’s absorbed, what does Metronidazole do?
Becomes toxic to bacterial DNA
Remember, it’s harmless to other microbes and only targets ANAEROBIC bacteria
Inhibits cell wall synthesis and promotes bacterial cell lysis and death
- similar to Beta-Lactams though it doesn’t interact w/ PBPs (proteins)
- instead it binds to molecules that serve as precursors for cell wall biosynthesis (the building blocks)
Metronidazole and Vancomycin are especially useful for treating what?
C. diff (STOP, SWAP, ZOLE)
STOP the other antibiotic
SWAP the hand foam for hand soap
metraonidaZOLE (or Vancomycin)
S/E for Metronidazole
- N/V (all antibiotics)
- Metallic Taste (similar to Macrolide) (metros [subways] are made of metal)
- Peripheral Neuropathy (tingling) (rare)
- Disulfrium (no alcohol)
Don’t drink what w/ Metronidazole?
disulfrium type reaction
S/E for Vancomycin
- Nephrotoxicity (hard on kidneys)
- Thrombophlebitis (hard on veins)
- Red Man Syndrome (release lots of histamine)
When on Vancomycin, what do we monitor?
- check blood levels (Vancomycin Trough)
- watch Serum Creatinine levels (if increase by 50%, lower dose)
When should we check Vancomycin Trough?
30 mins before next dose
How do we deal w/ the S/E of Vancomycin that it’s hard on veins?
Rotate IV sites
Red Man Syndrome is a S/E of which drug?
- causes itching, redness, tachycardia, hypotension (not anaphylaxis)
- slow down the infusion and give Benadryl
S/S of Red Man’s Syndrome
caused by Vancomycin
Patients allergic to penicillin —- have vancomycin.
Which two drugs work like a Trojan Horse?
Where do we typically use metronidazole?
Infections below the diaphragm b/c it works on anaerobic bacteria, which is found typically in the gut
Someone having abdominal surgery would take which antibiotic prophylactically?
b/c it works on anaerobic bacteria found in the gut
Treatment regimen for H. pylori (#1 cause of stomach ulcers)
- bismuth subsalicylate (Pepto-Bismol®).
- -prazole or -tidine
Common, not serious complication from vancomycin?
Redneck Syndrome (sunburn like redness)
Most commonly prescribed antibiotic in the hospital is —-
—— is a good alternative to people allergic to -cillin because it kills a lot of stuff.
Is Vancomycin lipid soluble?
So if taken PO it will not be absorbed and will stay in gut
ONLY give PO if infection is in GI tract.
V looks like a trough filled w/ urine
Always check the vancomycin trough 30 mins before next dose… usually before the 4th dose