Test 4 - Gout Medications (Josh) Flashcards Preview

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Flashcards in Test 4 - Gout Medications (Josh) Deck (14)
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1
Q

Pathophysiology of Gout

A

When a cell dies, the DNA spills out and eventually turns into uric acid

Uric acid is not H2O soluble and crystallizes, leading to redness, swelling of joint

2
Q

If Gout happens 2-3 year, use —

If Gout happens 4 or more times a year use —-

A

NSAIDs or Glucocorticoids

Gout Meds

  • allopurinol
  • cochinicine
3
Q

—– is the cornerstone of gout treatment.

A

Allopurinol

4
Q

—– is a uric acid lowering drug.

A

Allopurinol

Works by blocking enzymes (XOs) that turn DNA into Uric Acid

5
Q

How long does it take Allopurinol to take full effect?

A

1-2 months

6
Q

Why is allopurinol useful for certain cancers?

A

Cancer patient can get gout due to cancer cells being killed off and DNA turning into Uric Acid

Allopurinol it destroys the cancer cells that are broken when cancer cells die

7
Q

What tis the therapeutic goal when taking allopurinol?

A

Uric acid below 7 mg/dL in men and 6 mg/dL in women

8
Q

A/E of allopurinol?

A
  • Acute gouty attack (use NSAID to treat)
  • Hypersensitivity Syndrome
  • Hepatotoxicity
9
Q

A/D of colchicine

A
  • Diarrhea (25%)
  • Myopathy
  • Bone Marrow Suppression
10
Q

Which drug should be monitored when taking colchicine?

A

-statin

Due to Myopathy —> rhabdomyolysis

11
Q

What should we watch for in a client taking colchicine?

A

Bone Marrow Suppression

  • monitor WBC, RBC, Platelets
  • monitor for signs of ANEMIA
12
Q

At what point should a client move from NSAIDs and Glucocorticoids to a Irate-Lowering Med like allopurinol?

A

When gout happens more than 3-4 times per year

13
Q

If a client has a hypersensitive reaction while taking allopurinol, what should nurse do?

A

Stop the drug

14
Q

Most common S/E of colchicine?

A

Diarrhea (25 %)