B10 drugs

Question 1

Ramipril

Answer 1

ACE inhibitor given for hypertension and heart failure. Results in the increase in braykinin, which results in angioedema and dry cough. Cannot be given in pregnancy.

Question 2

Amiloride

Answer 2

K+ sparing diruetic given for hypertension. It inhibits sodium reabsorption in the DCT, promoting Na+ and H20 loss while retaining K+ and H+.

Question 3

Furosemide

Answer 3

Loop diuretic which inhibits Na-K-Cl reabsorption in the Loop of Henle and causes increase in prostaglandin.

Question 4

Bendroflumethiazide

Answer 4

Thiazide diuretic which inhibits the Na-CL transporter in the DCT

Question 5

Doxazosin

Answer 5

Alpha-1 adrenergic receptor blocker given for BPH and hypertension. Inhibited for micrutition syncope (fainting after urination) and anuria.

Question 6

Spironolactone

Answer 6

Mineralcorticoid antagonist at the DCT to prevent aldosterone receptor with a K+ sparing effect. Cannot be given for anuria and Addison’s disease.

Question 7

Indapamide

Answer 7

Thiazide-like diuretic which inhibits the Na-Cl transporter in the DCT which causes high levels of Ca2+. annot be given for Addison’s disease and hypercalcemia.