(16) CV3 SLO Flashcards Preview

Pharmacology > (16) CV3 SLO > Flashcards

Flashcards in (16) CV3 SLO Deck (43):
1

Anticoagulants are associated with an increased risk of __?__
A. Bleeding or hemorrhage
B. Stroke
C. GI upset and pain, gallstones and hepatotoxicity as well as myopathies.
D. Drug-induced skin necrosis
E. Severe flushing, hyperglycemia, hyperuricemia, GI distress, tachycardia, hyperpigmentation of the skin and drug-induced amblyopia.

Bleeding or hemorrhage

2

Cholestyramine is associated with __?__.
A. Drug-induced skin necrosis
B. Severe flushing, hyperglycemia, hyperuricemia, GI distress, tachycardia, hyperpigmentation of the skin and drug-induced amblyopia.
C. Flatulence, constipation or diarrhea, and it interferes with the absorption of other drugs and vitamins.
D. An increased risk of bleeding or hemorrhage
E. GI upset and pain, gallstones and hepatotoxicity as well as myopathies.

Flatulence, constipation or diarrhea, and it interferes with the absorption of other drugs and vitamins.

3

Cholestyramine may delay or reduce the absorption of other PO medications including warfarin, thiazide diuretics, propranolol, tetracycline, penicillin G, phenobarbital, thyroid preparations, estrogens & progestins, & digitalis as well as fat soluble vitamins (A, D, E, & K) . Therefore, it should be taken:
A. Actually, you can not give it with these medications at all. You have to change medications.
B. At the same time as other medications
C. It doesn’t matter when you give cholestyramine
D. 12 hours apart from other medications
E. 1 hour after or 6 hours before other medications

1 hour after or 6 hours before other medications

4

Dabigatran is associated with __?__
A. Flatulence, constipation or diarrhea, and it interferes with the absorption of other drugs and vitamins.
B. Severe flushing, hyperglycemia, hyperuricemia, GI distress, tachycardia, hyperpigmentation of the skin and drug-induced amblyopia.
C. Drug-induced skin necrosis
D. GI upset and pain, gallstones and hepatotoxicity as well as myopathies.
E. Dyspepsia, nausea, upper abdominal pain, GI hemorrhage and diarrhea

Dyspepsia, nausea, upper abdominal pain, GI hemorrhage and diarrhea

5

Factor IX complex is derived from pooled human plasma so a risk exists of __?__.
A. Severe flushing, hyperglycemia, hyperuricemia, GI distress, tachycardia, hyperpigmentation of the skin and drug-induced amblyopia.
B. Transmissible diseases including prion diseases and severe allergic reactions.
C. GI upset and pain, gallstones and hepatotoxicity as well as myopathies.
D. Flatulence, constipation or diarrhea
E. Drug-induced skin necrosis

Transmissible diseases including prion diseases and severe allergic reactions.

6

Gemfibrozil bioavailability is decreased by __?__, so take 30 minutes before __?__
A. Other drugs/taking another drug
B. Food/am and pm meal
C. All the listed answers are correct
D. GI motility/getting out of bed
E. Water/drinking anything

Food/am and pm meal

7

Gemfibrozil is associated with __?__.
A. Severe flushing, hyperglycemia, hyperuricemia, GI distress, tachycardia, hyperpigmentation of the skin and drug-induced amblyopia
B. GI upset and pain, gallstones and hepatotoxicity as well as myopathies.
C. Drug-induced skin necrosis
D. Flatulence, constipation or diarrhea, and it interferes with the absorption of other drugs and vitamins.
E. An increased risk of bleeding or hemorrhage

GI upset and pain, gallstones and hepatotoxicity as well as myopathies.

8

Giving Clopidogrel and any CYP2C19 inhibitor such as omeprazole (a proton pump inhibitor used to treat GERD) will __?__
A. Decrease clopidogrel levels and increase the risk of clots
B. Decrease clopidogrel levels, but increase the bleeding risk
C. Increase clopidogrel levels and decrease the risk of clots
D. Increase levels of clopidogrel and increase the risk of bleeding
E. Not alter the blood levels of clopidogrel

Decrease clopidogrel levels and increase the risk of clots

9

Giving Warfarin and any CYP2C9 inducer may lead to __?__
A. Decreased warfarin and improved treatment outcome
B. Decreased warfarin so less monitoring is required
C. Increased warfarin levels which decreases the risk of bleeding
D. Increased warfarin levels which requires more monitoring
E. Decreased warfarin and treatment failure (increased risk of clotting and embolism)

Decreased warfarin and treatment failure (increased risk of clotting and embolism)

10

Giving Warfarin and any CYP2C9 inhibitor or any drug heavily PPB will __?__
A. Increase warfarin levels and decrease the risk of bleeding
B. Not alter the blood levels of warfarin
C. Decrease warfarin levels, but increase the bleeding risk
D. Decrease warfarin levels and decrease the risk of bleeding
E. Increase levels of warfarin and increase the risk of bleeding

Increase levels of warfarin and increase the risk of bleeding

11

If Vitamin K is found in spinich and counters the effects of warfarin, a patient taking warfarin should be educated about:
A. Eating only Vitamin K rich foods, including spinich.
B. Keeping their consumption of Vitamin K containing foods, like spinich, consistent.
C. Limiting their consumption of Vitamin K rich foods.
D. Never consuming Vitamin K containing foods like spinich.
E. Eating lots of Vitamin K rich foods, including spinich.

Keeping their consumption of Vitamin K containing foods, like spinach, consistent.

12

In combination with statins, nicotinic acid is associated with __?__.
A. An increased risk of bleeding or hemorrhage
B. Flatulence, constipation or diarrhea, and it interferes with the absorption of other drugs and vitamins
C. GI upset and pain, gallstones and hepatotoxicity as well as myopathies
D. An increased risk of risk for hepatotoxicity, Rhabdomyolysis and angioedema
E. Drug-induced skin necrosis

An increased risk of risk for hepatotoxicity, Rhabdomyolysis and angioedema

13

Many Anticoagulants are associated with __?__.
A. GI upset and pain, gallstones and hepatotoxicity as well as myopathies.
B. Back pain
C. Drug-induced skin necrosis
D. Severe flushing, hyperglycemia, hyperuricemia, GI distress, tachycardia, hyperpigmentation of the skin and drug-induced amblyopia.
E. Flatulence, constipation or diarrhea.

Back pain

14

Many botanicals contain __?__ or have potential __?__ effects for other reasons (licorice, red clover, aloe, black cohosh, dandelion, feverfew, ginger, ginkgo biloba, ginseng).
A. Heparin/anticoagulant
B. Statins/lipid lowering
C. St John’s wort/P450
D. Coumarins/anticoagulant
E. None of these answers are correct.

Coumarins/anticoagulant

15

Minimize lapses in therapy with anticoagulants because discontinuing anticoagulants puts patients at increased risk of __?__.
A. An increased risk of bleeding or hemorrhage
B. Severe flushing, hyperglycemia, hyperuricemia, GI distress, tachycardia, hyperpigmentation of the skin and drug-induced amblyopia.
C. GI upset and pain, gallstones and hepatotoxicity as well as myopathies.
D. Stroke
E. Drug-induced skin necrosis

Stroke

16

Nicotinic acid is associated with __?__.
A. Drug-induced skin necrosis
B. Flatulence, constipation or diarrhea, and it interferes with the absorption of other drugs and vitamins.
C. An increased risk of bleeding or hemorrhage
D. GI upset and pain, gallstones and hepatotoxicity as well as myopathies.
E. Severe flushing, hyperglycemia, hyperuricemia, GI distress, tachycardia, hyperpigmentation of the skin and drug-induced amblyopia.

Severe flushing, hyperglycemia, hyperuricemia, GI distress, tachycardia, hyperpigmentation of the skin and drug-induced amblyopia.

17

Statins are associated with __?__.
A. Rhabdomyolysis
B. Gallstones
C. Hemorrhage
D. Flushing
E. Tachycardia

Rhabdomyolysis

18

Statins are associated with __?__.
A. Gallstones
B. Decreased HDL
C. Tachycardia
D. Increased LDL
E. Memory loss

Memory loss

19

Statins are commonly associated with __?__.
A. Blood dyscrasias
B. Suicide
C. Headache, flatulance, nausea
D. Hemorrhage
E. Flushing

Headache, flatulance, nausea

20


Warfarin is associated with __?__.
A. Hepatitis, jaundice and cholestatic hepatic injury
B. Increased risk of hemorrhage or bleeding
C. Drug-induced skin necrosis
D. Anaphylactic reactions, hypersensitivity
E. All the above

All the above

21

What is HIT?
A. Heparin-Induced Thirst
B. Heparin-Induced Thrombocytopenia
C. Hemorrhage Is Terrible
D. Hepatically-Induced Thrombocytopenia
E. Hepatic Inversion Test

Heparin-Induced Thrombocytopenia

22

Which of the following inhibits ADP receptors on platelets? It may be taken PO SID without regard to food. Indicated for CAD, PVD, and cerebrovascular disease. Patients must be screened for CYP2C19 activity prior to taking this drug.
A. Aminocaproic acid
B. Clopidogrel
C. Eptifibatide
D. Alteplase
E. Cilostazol

Clopidogrel

23

Which of the following inhibits cAMP (3-) PDE? It should be taken PO BID 30 minutes before or 2 hrs after meals. It is indicated for intermittent claudication.
A. Cilostazol
B. Eptifibatide
C. Clopidogrel
D. Aminocaproic acid
E. Aspirin

Cilostazol

24

Which of the following inhibits cholesterol absorption from the intestines? It is indicated PO SID as an adjunct to diet to decrease total-C, LDL-C, non-HDL-C and apo B.
A. Nicotinic acid
B. Gemfibrozil
C. Atorvastatin
D. Ezetimibe
E. Cholestyramine

Ezetimibe

25

Which of the following inhibits fibrinolysis (prevents the break down of clots)? Given PO or as an IV Infusion with a loading dose and then hourly up to about 8 hours. Indicated for hyperfibrinolytic states (conditions where clots don’t form such as certain cancers, heart surgery etc.)
A. Bivalirudin
B. Cilostazol
C. Alteplase
D. Factor IX complex
E. Aminocaproic acid

Aminocaproic acid

26

Which of the following inhibits glycoprotein IIB/IIIA receptors on platelets. Given IV only, it is indicated to prevent clots during angioplasty and in acute coronary syndrome (MI) patients. It is based on an anticoagulant protein found in snake spit.
A. Warfarin
B. Clopidogrel
C. Eptifibatide
D. Alteplase
E. Aminocaproic acid

Eptifibatide

27

Which of the following is a bile acid sequestrant indicated PO SID or BID as an adjunct to diet to reduce LDL-C and for the relief of pruritus associated with partial bile duct obstruction?
A. Ezetimibe
B. Atorvastatin
C. Nicotinic acid
D. Gemfibrozil
E. Cholestyramine

Cholestyramine

28

Which of the following is a direct thrombin inhibitor that can be taken orally?
A. Heparin
B. Clopidogrel
C. Enoxaparin
D. Bivalirudin
E. Dabigatran

Dabigatran

29

Which of the following is a fibric acid given PO BID 30 minutes before am and pm meals to lower TG levels (and raise HDL-C)?
A. Nicotinic acid
B. Cholestyramine
C. Ezetimibe
D. Atorvastatin
E. Gemfibrozil

Gemfibrozil

30

Which of the following is a HMG-CoA reductase inhibitor (statin) taken PO SID and indicated as an adjunct to diet to reduce the risk of MI/stroke/angina; to reduce levels of total cholesterol (C), LDL-C, Apo B and TG and to increase levels of HDL-C?
A. Atorvastatin
B. Cholestyramine
C. Gemfibrozil
D. Nicotinic acid
E. Ezetimibe

Atorvastatin

31

Which of the following is a LMWH given SC or IV SID for 7-17 days for DVT, and thrombosis/ischemia related to angina or MI?
A. Heparin
B. Enoxaparin
C. Bivalirudin
D. Cilostazol
E. Warfarin

Enoxaparin

32

Which of the following is a parenteral anticoagulant given IV to prevent thrombosis during cardiac procedures and in patients who can’t take heparin? It is based upon an anticoagulant protein found in leech spit.
A. Cilostazol
B. Heparin
C. Warfarin
D. Bivalirudin
E. Eptifibatide

Bivalirudin

33

Which of the following is a recombinant tissue plasminogen activator (t-PA) fibrinolytic drug? It activates a natural enzyme (plasminogen) that breaks apart clots. Given IV, it is indicated for acute MI, unstable angina, and lysis of objectively diagnosed thrombi in lungs or deep veins.
A. Aspirin
B. Alteplase
C. Warfarin
D. Aminocaproic acid
E. Clopidogrel

Alteplase

34

Which of the following is an anti-hemophilic agent (replaces clotting factors)? It is given IV only to control bleeding in hemophilia type B as well as for peri-operative management of bleeding in hemophilia type B.
A. Coumadin
B. Angiomax
C. Amicar
D. BeneFIX
E. Lovenox

BeneFIX

35

Which of the following is an oral anticoagulant available IV/IM/PO? Individualized therapy is required based on PT/INR response. It is indicated for venous thrombosis and pulmonary embolism, thromboembolism associated with atrial tachyarrhythmias or cardiac valve replacement. Given chronically SID/BID PO.
A. Clopidogrel
B. Eptifibatide
C. Warfarin
D. Cilostazol
E. Bivalirudin

Warfarin

36

Which of the following is given IV or deep SC to prevent thrombosis? It is known to cause thrombocytopenia and with long-term use, osteoporosis.
A. Bivalirudin
B. Clopidogrel
C. Aspirin
D. Warfarin
E. Heparin

Heparin

37

Which of the following is niacin? The PO doses BID/TID must be individualized up to 2 grams/day. It is an adjunct to diet and usually another drug (Questran) to lower LDL-C and TG?
A. Cholestyramine
B. Atorvastatin
C. Nicotinic acid
D. Gemfibrozil
E. Ezetimibe

Nicotinic acid

38

Which of the following was developed based on research into a fungal toxin that poisoned a herd of cattle in Wisconsin?
A. Eptifibatide
B. Bivalirudin
C. Heparin
D. Cilostazol
E. Warfarin

Warfarin

39

Which of the following was developed based on research into leech spit?
A. Bivalirudin
B. Warfarin
C. Heparin
D. Eptifibatide
E. Cilostazol

Bivalirudin

40

Which of the following was developed based on research into Southeastern Pigmy Rattlesnake spit?
A. Warfarin
B. Cilostazol
C. Bivalirudin
D. Heparin
E. Eptifibatide

Eptifibatide

41

Which of these sets has anticoagulant properties due to effects on platelets? In other words, they ARE anti-platelet anticoagulants.
A. Alteplase, Aminocaproic acid and BeneFIX
B. Dabigatran, Cilostazol, and Clopidogrel
C. Enoxoparin, Aspirin, and Eptifibatide
D. Clopidogrel, Aspirin, Eptifibatide, and Cilostazol
E. Warfarin, Heparin, Enoxoparin, Bivalirudin and Dabigatran

Clopidogrel, Aspirin, Eptifibatide, and Cilostazol

42

Which of these sets has anticoagulant properties due to effects on the activity of clotting cascade proteins? In other words, they are not anti-platelet anticoagulants.
A. Alteplase, Aminocaproic acid and BeneFIX
B. Dabigatran, Cilostazol, and Clopidogrel
C. Enoxoparin, Aspirin, and Eptifibatide
D. Clopidogrel, Aspirin, Eptifibatide, and Cilostazol
E. Warfarin, Heparin, Enoxoparin, Bivalirudin and Dabigatran

Warfarin, Heparin, Enoxoparin, Bivalirudin and Dabigatran

43

Which pair is most alike?
A. Dabigatran and Clopidogrel
B. Cilostazol and Bivalirudin
C. Heparin and Enoxaparin
D. Aspirin and Eptifibatide
E. Warfarin and Heparin

Heparin and Enoxaparin