(24) Viruses SLO Flashcards Preview

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Flashcards in (24) Viruses SLO Deck (30):
1

A client is prescribed 5% Zovirax ointment to treat genital herpes. Which of these statements made by the client indicates you have been successful at teaching a very important concept related to acyclovir?
A. "Using this product will not prevent me from transmitting herpes to another person."
B. "I will clean the infected area every other day with soap and water."
C. "I will keep the area covered to prevent transmission of herpes to another person."
D. "I will start applying the ointment as soon as the lesions crust over."
E. All of the above are correct

"Using this product will not prevent me from transmitting herpes to another person."

2

Interferon alfa 2 b is associated with __?__
A. Renal toxicity and seizures
B. Hemolytic anemia and fetotoxicity
C. Causing suicidal ideation and behavior, autoimmune and ischemic disorders and infections
D. Mitochondrial toxicity that leads to lactic acidosis
E. Body fat alterations and altered lipid metabolism

Causing suicidal ideation and behavior, autoimmune and ischemic disorders and infections

3

Lamivudine is prescribed to your client to treat chronic Hepatitis B. Your will teach your client to immediately report signs and symptoms of __?__ a potentially life-threating side effect of this drug that includes panting, shortness of breath, anxiety, and palpitations or rapid heart rate.
A. Heart failure
B. Liver failure
C. Lactic acidosis
D. Kidney failure
E. Systemic yeast superinfection

Lactic acidosis

4

Protease Inhibitors are associated with __?__
A. Hemolytic anemia and fetotoxicity
B. Suicidal ideation, autoimmune and ischemic disorders and infections
C. Hypertriglyceridemia
D. Renal toxicity and seizures
E. Mitochondrial toxicity that leads to lactic acidosis

Hypertriglyceridemia

5

Ritonovir is used to increase the t ½ of __?__
A. Antibiotics like the penicillins
B. All HIV medications
C. Protease Inhibitors
D. Reverse Transcriptase inhibitors
E. Fusion Inhibitors

Protease Inhibitors

6

The acronym HAART means __?__
A. HIV Alternative Additional Retroviral Therapy
B. Highly Active Anti Retroviral Therapy
C. Hotly Argued Anti Retroviral Term
D. Highly Anticipated Advanced Retroviral Therapy
E. Hardly Appropriate Adult Review Themes

Highly Active Anti Retroviral Therapy

7

What does “Boosting “ mean with regards to HIV therapy?
A. Stealing drugs in order to get the amounts needed
B. Adding on additional amounts of drug, or increasing the frequency of dosing
C. Using one drug to increase the t ½ of another
D. Getting high off the anti retroviral drugs
E. Adding on additional drugs to the combination therapy

Using one drug to increase the t ½ of another

8

What is the antiviral mechanism of Acyclovir (Zovirax)?
A. It is a saturated fatty acid with unknown mechanism, OTC topical for oral and facial HSV
B. It is a fake nucleoside, once incorporated into viral DNA, it prevents elongation of DNA because the viral enzymes can’t fix the error. Used to treat Herpes simplex (HSV) and Varicella zoster (VZV – chicken pox).
C. It inhibits ion channel M2 protein in Influenza A virus; also NMDA antagonist and anticholinergic for EPS & PD
D. It inhibits neuraminidase preventing Influenza A infection (virus can’t enter cell)
E. It has an unknown mechanism and used topically to treat genital and perianal warts caused by the Human Papilloma Virus (HPV) and some skin cancers.

It is a fake nucleoside, once incorporated into viral DNA, it prevents elongation of DNA because the viral enzymes can’t fix the error. Used to treat Herpes simplex (HSV) and Varicella zoster (VZV – chicken pox).

9

What is the antiviral mechanism of Atazanavir (Reyataz)?
A. It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly
B. It is a fake nucleoside used to treat CMV retinitis only
C. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV
D. It is a fake nucleoside used to treat Herpes Simplex Virus (HSV) and Varicella.
E. It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV

It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly

10

What is the antiviral mechanism of Darunavir (Prezista)?
A. It is a fake nucleoside used to treat CMV retinitis only
B. It is a fake nucleoside used to treat Herpes Simplex Virus (HSV) and Varicella.
C. It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly
D. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV
E. It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV

It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly

11

What is the antiviral mechanism of Docosanol (Abreva)?
A. It is a saturated fatty acid with unknown mechanism, OTC topical for oral and facial HSV
B. It has an unknown mechanism and used topically to treat genital and perianal warts caused by the Human Papilloma Virus (HPV) and some skin cancers.
C. It inhibits ion channel M2 protein in Influenza A virus; also NMDA antagonist and anticholinergic for EPS & PD
D. It is a fake nucleoside, once incorporated into viral DNA, it prevents elongation of DNA because the viral enzymes can’t fix the error. Used to treat Herpes simplex (HSV) and Varicella zoster (VZV – chicken pox).
E. It inhibits neuraminidase preventing Influenza A infection (virus can’t enter cell)

It is a saturated fatty acid with unknown mechanism, OTC topical for oral and facial HSV

12

What is the antiviral mechanism of Efavirenz (Sustiva)?
A. It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV
B. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV
C. It is a fake nucleoside used to treat Herpes Simplex Virus (HSV) and Varicella.
D. It is a fake nucleoside used to treat CMV retinitis only
E. It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly

It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV

13

What is the antiviral mechanism of Emtricitabine (Emtriva)?
A. It is a fake nucleoside used to treat Herpes Simplex Virus (HSV) and Varicella.
B. It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV
C. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV
D. It is a fake nucleoside used to treat CMV retinitis only
E. It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly

It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV

14

What is the antiviral mechanism of Enfuviratide (Fuzeon)?
A. It blocks a cell surface receptor, called CCR5, used by HIV to enter cells
B. It is a Protease Inhibitor (PI) used in HAART for HIV and potent P450 inhibitor so it prolongs the t 1/2 of all the other PIs. Used in HIV HAART. PIs block viral particle assembly
C. Fusion inhibitor (FI) for HIV HAART.
D. It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV
E. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV

Fusion inhibitor (FI) for HIV HAART.

15

What is the antiviral mechanism of Fosamprenavir (Lexiva, Telzer)?
A. It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV
B. It is a fake nucleoside used to treat Herpes Simplex Virus (HSV) and Varicella.
C. It is a fake nucleoside used to treat CMV retinitis only
D. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV
E. It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly

It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly

16

What is the antiviral mechanism of Foscarnet (Foscavir)?
A. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV
B. It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV
C. It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly
D. It is a fake nucleoside used to treat Herpes Simplex Virus (HSV) and Varicella.
E. It is a fake nucleoside used to treat CMV retinitis only

It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV

17

What is the antiviral mechanism of Ganciclovir (Vitrasert)?
A. It is a fake nucleoside used to treat Herpes Simplex Virus (HSV) and Varicella.
B. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV
C. It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly
D. It is a fake nucleoside used to treat CMV retinitis only
E. It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV

It is a fake nucleoside used to treat CMV retinitis only

18

What is the antiviral mechanism of Imiquimod (Aldara)?
A. It is a saturated fatty acid with unknown mechanism, OTC topical for oral and facial HSV
B. It has an unknown mechanism and used topically to treat genital and perianal warts caused by the Human Papilloma Virus (HPV) and some skin cancers.
C. It inhibits ion channel M2 protein in Influenza A virus; also NMDA antagonist and anticholinergic for EPS & PD
D. It is a fake nucleoside, once incorporated into viral DNA, it prevents elongation of DNA because the viral enzymes can’t fix the error. Used to treat Herpes simplex (HSV) and Varicella zoster (VZV – chicken pox).
E. It inhibits neuraminidase preventing Influenza A infection (virus can’t enter cell)

It has an unknown mechanism and used topically to treat genital and perianal warts caused by the Human Papilloma Virus (HPV) and some skin cancers.

19

What is the antiviral mechanism of Lamivudine (Epivir)?
A. It is an RTI used to treat HCV with Interferon alfa 2b.
B. It is a Protease Inhibitor (RTI) used in HAART for HIV
C. It blocks a cell surface receptor used by HIV to enter cells called CCR5.
D. Fusion inhibitor (FI) for HIV HAART. FI block entry of the virus into the cell.
E. It is an RTI used to treat Hepatitis B (HBV)

It is an RTI used to treat Hepatitis B (HBV)

20

What is the antiviral mechanism of Lopinavir (Aluvia)?
A. It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly
B. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV
C. It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV
D. It blocks a cell surface receptor, called CCR5, used by HIV to enter cells
E. Fusion inhibitor (FI) for HIV HAART.

It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly

21

What is the antiviral mechanism of Maraviroc (Selzentry)?
A. It is a Protease Inhibitor (PI) used in HAART for HIV and potent P450 inhibitor so it prolongs the t 1/2 of all the other PIs. Used in HIV HAART. PIs block viral particle assembly
B. Fusion inhibitor (FI) for HIV HAART.
C. It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV
D. It blocks a cell surface receptor, called CCR5, used by HIV to enter cells
E. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV

It blocks a cell surface receptor, called CCR5, used by HIV to enter cells

22

What is the antiviral mechanism of Nevirapine (Viramune)?
A. It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly
B. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV
C. It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV
D. It is a fake nucleoside used to treat Herpes Simplex Virus (HSV) and Varicella.
E. It is a fake nucleoside used to treat CMV retinitis only

It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV

23

What is the antiviral mechanism of Ribavirin (Rebetol)?
A. It is an RTI used to treat Hepatitis B (HBV)
B. It is a Protease Inhibitor (RTI) used in HAART for HIV
C. It is an RTI used to treat HCV with Interferon alfa 2b.
D. Fusion inhibitor (FI) for HIV HAART. FI block entry of the virus into the cell.
E. It blocks a cell surface receptor used by HIV to enter cells called CCR5.

It is an RTI used to treat HCV with Interferon alfa 2b

24

What is the antiviral mechanism of Ritonavir (Norvir)?
A. It blocks a cell surface receptor, called CCR5, used by HIV to enter cells
B. It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV
C. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV
D. Fusion inhibitor (FI) for HIV HAART.
E. It is a Protease Inhibitor (PI) used in HAART for HIV and potent P450 inhibitor so it prolongs the t 1/2 of all the other PIs. Used in HIV HAART. PIs block viral particle assembly

It is a Protease Inhibitor (PI) used in HAART for HIV and potent P450 inhibitor so it prolongs the t 1/2 of all the other PIs. Used in HIV HAART. PIs block viral particle assembly

25

What is the antiviral mechanism of Telbivudine (Tyzeka)?
A. Fusion inhibitor (FI) for HIV HAART. FI block entry of the virus into the cell.
B. It blocks a cell surface receptor used by HIV to enter cells called CCR5.
C. It is a Protease Inhibitor (RTI) used in HAART for HIV
D. It is an RTI used to treat Hepatitis B (HBV)
E. It is an RTI used to treat HCV with Interferon alfa 2b.

It is an RTI used to treat Hepatitis B (HBV)

26

What is the antiviral mechanism of Tenofovir (Viread)?
A. It is a fake nucleoside used to treat CMV retinitis only
B. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV
C. It is a fake nucleoside. Used to treat Cytomegalovirus (CMV) and acyclovir resistant HSV
D. It is a Protease Inhibitor (PI) used in HAART for HIV and boosted with Ritonovir. PIs block viral particle assembly
E. It is a fake nucleoside used to treat Herpes Simplex Virus (HSV) and Varicella.

It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV

27

What is the mechanism of Probenecid (Benuryl)?
A. It blocks absorption
B. It increases excretion through the kidneys
C. It induces P450s
D. It inhibits renal tubular secretion of many drugs and is used to treat gout
E. It inhibits P450s

It inhibits renal tubular secretion of many drugs and is used to treat gout

28

__?__ are associated with mitochondrial toxicity that leads to lactic acidosis.
A. Fusion Inhibitors
B. RTIs
C. CCR5 inhibitors
D. PIs
E. Immune modulators

RTIs

29

Miraviroc only works in people with __?__
A. CCR5-trophic HIV-1
B. Treatment experience (they have had other HIV drugs)
C. Hepatitis B or C (HBV or HCV)
D. Human Papilloma virus (HPV)
E. Herpes

CCR5-trophic HIV-1

30

What is the antiviral mechanism of Interferon alfa 2b (Intron A)?
A. It is an RTI used to treat HCV
B. It blocks a cell surface receptor used by HIV to enter cells called CCR5
C. It is a Reverse Transcriptase Inhibitor (RTI) used in HAART for HIV
D. It is an RTI used to treat Hepatitis B (HBV)
E. It is an immune modulator used alone for HBV and with Ribavirin for HCV.

It is an immune modulator used alone for HBV and with Ribavirin for HCV.