(21) Micro 5 SLO Flashcards Preview

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Flashcards in (21) Micro 5 SLO Deck (17):
1

Amphotericin B is associated with __?__
A. Numerous drug interactions due to P450 inhibition
B. 8th cranial nerve damage
C. Fever, shaking, chills, hypotension, anorexia, nausea, vomiting, headache and tachypnea.
D. Liver failure, severe allergic reactions and arrhythmias.
E. None of the listed answers are correct

Fever, shaking, chills, hypotension, anorexia, nausea, vomiting, headache and tachypnea

2

Fluconazole (Diflucan) is a potent P450 inhibitor with lots of drug interactions. What is the general effect on drugs having fluconazole interaction problems?
A. Treatment failure occurs due to decreasing levels of the other drug
B. Cancer develops
C. Toxicity occurs due to increasing the levels of the “other” drug
D. Treatment failure occurs for the condition treated by fluconazole
E. No effect on treatment occurs

Toxicity occurs due to increasing the levels of the “other” drug

3

Fluconazole is a associated with __?__
A. Liver failure, severe allergic reactions and arrhythmias.
B. Numerous drug interactions due to P450 inhibition
C. Fever, shaking, chills, hypotension, anorexia, nausea, vomiting, headache and tachypnea.
D. All the above
E. A & B only

A & B only

4

Pyrantel is a fairly potent NMJB. Why does Pyrantel kill pinworms in the GIT, but not the human who “owns” said GIT?
A. It is rapidly metabolized in people
B. Because it is so poorly absorbed
C. It is a Prodrug that must be activated
D. It is specific for invertebrates
E. Gastrointestinal bacteria break it down

Because it is so poorly absorbed

5

The half life of fluconazole is increased by __?__
A. Hydrochlorothiazide
B. NSAIDs
C. Warfarin
D. Highly plasma protein bound drugs

Hydrochlorothiazide

6

What is a Pediculicide used for?
A. To kill fungi
B. To kill lice
C. To kill bacteria
D. To kill mites
E. To kill worms

To kill lice

7

What is a Scabicide used for?
A. To kill worms
B. To kill lice
C. To kill bacteria
D. To kill fungi
E. To kill mites

To kill mites

8

What is an Anthelmintic used for?
A. To kill lice
B. To kill bacteria
C. To kill mites
D. To kill fungi
E. To kill worms

To kill worms

9

What is an antifungal used for?
A. To kill fungi
B. To kill mites
C. To kill worms
D. To kill bacteria
E. To kill lice

To kill fungi

10

Which anthelmintic has an unknown mechanism of action?
A. Pyrantel
B. Praziquantel
C. Ivermectin
D. Albendazole
E. Diethylcarbamazine

Praziquantel

11

`Which anthelmintic inhibits arachidonic acid metabolism in microfilaria?
A. Ivermectin
B. Praziquantel
C. Pyrantel
D. Albendazole
E. Diethylcarbamazine

Diethylcarbamazine

12

Which anthelmintic is a NMJB (but, poorly absorbed in humans)?
A. Albendazole
B. Diethylcarbamazine
C. Pyrantel
D. Praziquantel
E. Ivermectin

Pyrantel

13

Which antifungal is a highly specific P450 inhibitor available PO and IV?
A. Clotrimazole
B. Albendazole
C. Praziquantel
D. Fluconazole
E. Amphotericin B

Fluconazole

14

Which antifungal is available OTC and by prescription for use as a topical treatment for ringworm and for candida infections?
A. Amphotericin B
B. Clotrimazole
C. Fluconazole
D. Praziquantel
E. Albendazole

Clotrimazole

15

Which antifungal is only used IV and only against life threating fungal infections?
A. Praziquantel
B. Albendazole
C. Amphotericin B
D. Fluconazole
E. Clotrimazole

Amphotericin B

16

Which of the following inhibits polymerization of worm tubulin into microtubules?
A. Pyrantel
B. Diethylcarbamazine
C. Albendazole
D. Praziquantel
E. Ivermectin

Albendazole

17

Which of the following opens glutamate-gated chloride channels in invertebrate nerve and muscle cells?
A. Praziquantel
B. Albendazole
C. Ivermectin
D. Pyrantel
E. Diethylcarbamazine

Ivermectin