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Flashcards in (8) Pain SLO Deck (30):

Acetaminophen is associated with __?__.
A. Bronchoconstriction
B. Liver failure
C. Urticaria
D. Reye’s Syndrome
E. Hyperkalemia

Liver Failure


Aspirin is associated with __?__ in kids with viral infections.
A. Reye’s Syndrome
B. GIT ulcers
C. Respiratory distress Syndrome
D. Urticaria
E. Constipation

Reye's Syndrome


Aspirin is associated with __?__
A. Gastric ulcers
B. Respiratory distress Syndrome (bronchoconstriction)
C. Urticaria
D. Tinnitus
E. All the above

Gastric ulcers
Respiratory distress Syndrome (bronchoconstriction)


Aspirin is contraindicated in young patients with chicken pox or influenza due to the risk of __?__
A. Reye’s Syndrome
B. Heart Attack
C. Gastric ulcer
D. Nose bleed
E. Asthma attack

Reye’s Syndrome


Etanercept, and other biologic response modifier or disease-modifying antirheumatic drugs (DMARDs) and other immune modulators, are associated with __?__.
A. Fewer infections
B. Antibiotic effects
C. Increased risk of malignancy
D. No change in immune response
E. An increased risk of serious infection and pancytopenia

An increased risk of serious infection and pancytopenia


Fentanyl and morphine have short t ½ so are used to treat acute or break through pain, whereas __?__ has a very long t ½ so is used for chronic pain.
A. Pentazocine
B. Hydrocodone
C. Meperidine
D. Naltrexone
E. Methadone



Hydrocodone is metabolized by CYP2D6 to morphine, genetic expression varies. Having multiple copies of the gene would predispose the patient to __?__ related side effects?
A. Cocaine
B. Morphine
C. Aspirin
D. Acetaminophen
E. Fentanyl



NSAIDs are associated with __?__.
A. GIT ulcers
B. GIT pain, nausea and aggravation of pre-existing GIT diseases
C. Urticaria
D. Worsening congestive heart failure
E. All the above

GIT ulcers
GIT pain, nausea and aggravation of pre-existing GIT diseases
Worsening congestive heart failure


Opioids are associated with __?__
A. Progressively decreased responsiveness so more drug is needed to get same effect.
B. Causing an overwhelming desire to take the drug
C. Tolerance
D. Dependence
E. All the above

Progressively decreased responsiveness so more drug is needed to get same effect.
Causing an overwhelming desire to take the drug


Probenecid (Benuryl) increases the __?__ of penicillin antibiotics, sulfonamides and sulfonylureas.
A. Renal secretion
B. Plasma concentration
C. Kidney excretion
D. Plasma protein binding
E. Liver metabolism

Plasma consentration


Which is a synthetic opioid analgesic available PO, SC, IV, IM, PR, sublingual, and buccal for moderate to severe pain? T ½ is 5-7 hours. It is NOT CONTROLLED.
A. Methadone
B. Tramadol
C. Pentazocine
D. Meperidine
E. Buprenorphine

Tramadol (Ultram)


Which blocks renal tubular reabsorption of urate? It is used to increase uric acid excretion, to treat gout, and to decrease the renal secretion of penicillin antibiotics.
A. Rasburicase
B. Etanercept
C. Colchicine
D. Probenecid
E. Allopurinol

Probenecid (Benuryl)


Which is a C-II opioid analgesic used PO, IM, IV, PR, epidural, and intrathecal with a t ½ of 1.5-7 hours to relieve moderate to severe pain? It is derived from the poppy and is commonly used in patient controlled analgesia devices (PCA).
A. Hydrocodone
B. Fentanyl
C. Morphine
D. Diphenoxylate
E. Naltrexone

Morphine (MS Contin)


Which is a C-II synthetic opioid analgesic available PO, IV, and IM for acute pain and obstetric or post-op analgesia? T ½ is about 3-4 hours. It has a boxed warning limiting use to less than 12 weeks.
A. Meperidine
B. Fentanyl
C. Methadone
D. Morphine
E. Buprenorphine

Meperidine (Demerol)


Which is a C-II synthetic opioid analgesic available PO, IV, IM, SC (IM and SC not preferred) to treat chronic pain, opioid addiction and as an antitussive? T ½ highly variable 24-60 hours.
A. Morphine
B. Fentanyl
C. Buprenorphine
D. Methadone
E. Meperidine

Methadone (Dolophine, Methadose)


Which is a C-II synthetic opioid analgesic indicated for chronic pain, MI and cancer, including breakthrough pain associated with injuries and cancer. IV, IM, PO, TD, sublingual & buccal formulations are available & the t ½ is about 7 hours.
A. Buprenorphine
B. Hydrocodone
C. Fentanyl
D. Methadone
E. Morphine

Fentanyl (Duragesic)


Which is a C-III synthetic opioid analgesic available sublingual (film and pills), TD, IM, and IV to treat moderate to severe chronic pain, opioid dependence and as a peri-op analgesic? T ½ is around 37 hours, but can be up to 70 hours.
A. Fentanyl
B. Methadone
C. Meperidine
D. Buprenorphine
E. Morphine

Buprenorphine (Buprenex, Suboxone)


Which is a C-IV synthetic opioid analgesic available IV, SC, IM and PO (formulated with naloxone to prevent abuse)? It is indicated for mild to moderate pain and as a pre-anesthetic or supplement to general anesthetic. T ½ is 2-3 hours.
A. Meperidine
B. Buprenorphine
C. Methadone
D. Fentanyl
E. Pentazocine

Pentazocine (Talwin)


Which is a C-V if compounded with atropine (C-II without). It is a congener of meperidine used PO as an antidiarrheal. The t ½ is 12-14 hours.
A. MS-Contin
B. Lomotil
C. Revia
D. Vicodin
E. Duragesic

Lomotil (Diphenoxylate + atropine)


Which is a CIII semi-synthetic opioid analgesic and antitussive? In the US, it is always compounded with something else like APAP or Atropine. It is given PO and the T ½ is about 4 hours.
A. Fentanyl
B. Morphine
C. Diphenoxylate
D. Hydrocodone
E. Naltrexone



Which is a COX2 inhibitor NSAID indicted for osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, acute pain, dysmenorrhea and colorectal polyps in Familial Adenomatous Polyposis (FAP). PO Only
A. Aspirin
B. Celecoxib
C. Acetaminophen
D. Ibuprofen
E. Paracetamol

Celecoxib (Celebrix)


Which is a glucosaminoglycan indicated to replace naturally occurring glucosaminoglycans in wounds (as wound dressing), and in osteoarthritis and eye surgery as well as to smooth out facial wrinkles and to treat dry, scaly skin?
A. Aspirin
B. Rasburicase
C. Ibuprofen
D. Hyaluronic acid
E. Acetaminophen

Hyaluronic Acid (Hyalgan)


Which of the following is a mitotic spindle poison used to treat gout?
A. Allopurinol
B. Colchicine
C. Rasburicase
D. Probenecid
E. Aspirin

Colchicine (Colcyrus)


Which is a salicylate NSAID?
A. Aspirin
B. Acetaminophen
C. Paracetamol
D. Celecoxib
E. Ibuprofen



Which is a Tissue necrosis factor alpha (TNF-alpha) inhibitor indicated to treat rheumatoid conditions? Only available SC.
A. Etanercept
B. Enbrel
C. Hyaluronic acid
D. A & B
E. A & C

Etanercept (Enbrel)


Which is a Xanthine oxidase inhibitor that blocks urate synthesis to treat gout? It is also used to treat the hyperurecemia associated with certain cancer chemotherapeutic agents.
A. Probenecid
B. Colchicine
C. Caffeine
D. Allopurinol
E. Rasburicase

Allpurinol (Zyloprim)


Which is an antipyretic analgesic AKA APAP?
A. Paracetamol
B. Acetaminophen
C. N-acetyl-para-aminophenol
D. Tylenol
E. All the above



NSAIDs are associated with __?__.
A. Water loss (diuresis)
B. Salt loss
C. Salt loss and water retention
D. Salt and water retention leading to edema and hyperkalemia
E. Salt retention leading to hyperkalemia and water loss

Salt and water retention leading to edema and hyperkalemia


NSAIDs are associated with __?__.
A. Urticaria
B. Bronchoconstriction
C. Tinnitus
D. Gastric ulcers
E. All the above

All the above


Opioids are associated with __?__.
A. CNS depression
B. Sedation
C. Constipation
D. Respiratory depression
E. All the above

All the above