5.1 Cells N Tissues Adapt Immunity Thymus

Question 1

B cells complete most of their development in?

Answer 1

the bone marrow in all animals, except birds

Question 2

In birds, B cells complete their development in?

Answer 2

a special organ at the hindgut called the Bursa of Fabricius

Question 3

Each mature B cell produces antigen specific?

Answer 3

receptors (Igs)

Question 4

Where and when do mature B cell produces antigen specific receptors (Igs)?

Answer 4

at the cell membrane when they are released from the bone marrow

Question 5

Mature naïve B cells express on their cell surface?

Answer 5

IgM and IgD

Question 6

Effector B cells secrete? and are called?

Answer 6

IgG, IgA, IgM, or IgE and are called B plasma cells

Question 7

Memory B cells express? where?

Answer 7

IgG, IgA, or IgE on their cell surface

Question 8

Secondary Lymphoid organs are sites where WHAT originates?

Answer 8

adaptive immune responses to antigen originate

Question 9

Lymph nodes are? Amount? Location?

Answer 9

a secondary type of lyphoid organs

*-500-600 nodes that run along the lymphatic channels

Question 10

Each lymph node has afferent lymphatic vessels that allow for entry of?

Answer 10

antigen with or without the help of macrophage lineage cells

Question 11

B-cells and T-cells are located where in the lymph node?

Answer 11

• -T cells are present in the paracortical areas of the cortex
• -B cells are in follicles of the cortex

Question 12

Ongoing immune responses take place in the?

Answer 12

germinal center of secondary follicle of the lymph node

Question 13

What percent of B-cells and T-cells are in the Germinal Center?

Answer 13

• -95% dividing B cells, dying B cells, or B cells changing into plasma cells
• -5% T cells which are helping out the B cell response

Question 14

Some plasma cells migrate to the? (Germinal Center)

Answer 14

medulla of lymph node

Question 15

plasma cells in the medulla of lymph nodes secrete ____ that flows into ____? (Germinal Center)

Answer 15

secrete antibody that flows into efferent lymphatics

Question 16

If they don’t migrate to the medulla, B cells migrate from the efferent lymphatics to? (Germinal Center)

Answer 16

the bone marrow where they secrete antibody

Question 17

some T cells migrate out through efferent lymphatics to go to site of infection. What T cell type is this?

Answer 17

CD8 T cells that are now cytotoxic T cells

*remember they are specific to viral infected cells

Question 18

Th1 CD4 T cells that help out?

Germinal Center

Answer 18

inflammatory macrophage responses and their own cytotoxic T cell responses

Question 19

Th17 CD4 T cells that help out?

Germinal Center

Answer 19

neutrophil responses

Question 20

primary vs scondary follicles?

Answer 20

primary= no immune response, resting B-cells
secondary= are going through immune response, contain responding B-cells in germinal center

Question 21

What two areas of lymph node contain resting B-cells?

Answer 21

primary follicle and marginal zone

Question 22

What three areas of lymph node contain T-cells?

Answer 22

• paracortex
• interfollicular zone
• 5% T-cells in germinal center (CD 4 Th2 and Tfh)

Question 23

What type of T-cells are found in germinal center? What do they do?

Answer 23

CD4 Th2 and Tfh (only 5%)

*help proliferate, trasition to plasma cells, move to medulla, and know which Ig to make

Question 24

B plasma cells migrate from secondary folliclular germinal center to either the lymph node medulla or back to bone marrow. Where do they survive longer?

Answer 24

Bone marrow= 3 weeks; therefore we think most of free floating plasma cells in circulation come from bone marrow

Lymph node= 3 days