mt.3 Antigen Antibody Lec 6

Question 1

What are factors that affect antibody response?

Answer 1

• route
• dose
• gender
• age
• nutrition
• Major Histocompatibility Complex (MHC)

Question 2

What are the two types of route?

Answer 2

systemic route

mucosal route

Question 3

define systemic route

Answer 3

lead to more IgG than IgA or IgM, which are all much higher than IgE

Question 4

define mucosal route

Answer 4

intranasal, inhalation, oral- leads to more IgA than IgM but little IgG

Question 5

define dose

Answer 5

each antigen has an optimum dose to yield the optimum levels of antibody.

• Lower doses lead to lower levels of antibody.
• Higher than optimum doses lead also to lower levels of antibody

Question 6

females or males have a higher antibody response?

Answer 6

females

Question 7

how does age affect antibody response?

Answer 7

• Infants have poor antibody responses.
• As a person matures the immune system also matures and the antibody responses increase.
• Elderly people begin to have poor antibody responses again

Question 8

how does nutrition affect antibody response?

Answer 8

Malnutrition leads to poor immune responses

Question 9

Major Histocompatibility Complex (MHC) affect on antibody responses?

Answer 9

genes lead to

1) poor immune responses to some antigens
2) good immune responses to some antigens
3) superior immune response to some antigens

Question 10

what end of the immunoglobulin is anchored in the membrane?

Answer 10

the carboxylterminal end

Question 11

IgG acquired immune response exhibits?

Answer 11

memory or and anamnestic response

Question 12

IgA acquired immune response exhibits?

Answer 12

memory or and anamnestic response of the mucosal immune system

Question 13

what does anamnestic mean?

Answer 13

denoting an enhanced reaction of the body’s immune system to an antigen that is related to an antigen previously encountered

Question 14

what is ‘primary immunogenic stimulus’?

Answer 14

first expossure to antigens

peyers pathces

Question 15

what is ‘latent period’

Answer 15

a stretch of time where no antibodies activity is observed after exposure

Question 16

difference between primary and secondary immunogenic stimulus?

Answer 16

second has longer latent period, great Ig response, shows ‘booster’ effect

Question 17

what is anamnestic mean?

Answer 17

memory

*Igs did NOT forget, so by second exposure you’ll have greater response

Question 18

IgE shows up in?

Answer 18

allergenic responses

Question 19

What Ig is most common to be made, in mucus and in allergenic responses?

Answer 19

common= IgG
mucus= IgA
allergies= IgE

Question 20

what Ig is made first almost every time?

Answer 20

IgM