6.2 Antigen Antibody Lec 6 Flashcards
B cell Adaptive immunity utilizes what to recognize antigen?
surface antibody (immunoglobulin) *THOSANDS of immunoglobulins on each B-cell
B cell can directly bind antigen
in its? why is this important
native configuration (NO processing required) **so it can bind back and react to the SAME antigen
What is required for B cell adaptive immunity to recognize antiegn?
both the sequence of amino acids and the three dimensional configuration of the antigen are required
ANTIGENS have a three dimensional structure
primary structure
secondary structure
tertiary structure
primary structure
Sequence of amino acids-1 or 2 dimensional
secondary structure
Biochemistry of the stretch of amino acids determines secondary structure
*beta sheets AND alpha helixe
tertiary structure
Association of all of the patterns determines final conformation
T cell Adaptive immunity utilizes what to recognize antigen?
utilizes a T Cell Receptor (TCR) for to recognize antigen
TCR cannot bind _____ antigen? T-cells require that?
native (unlike B-cell)
*T-cells require that the antigen be processed with histocompatibility molecules and presented by antigen presenting cell
for TCR to work, antigens must first be?
processed and presented by antigen presenting cells
TCR can only “see” an antigens peptide IF?
peptide of antigen is bound with histocompatibility molecules
what are antigen presenting cells for CD4+ T cells?
macrophages, dendritic cells, and even B cells (breaks antigen down to about 8 AA long)
what are antigen presenting cells for CD8+ T cells?
could be any cell infected by a virus or a cell that develops a mutation
*can also be macrophages, dendritic cells, and even B cells (just same as CD4+)
Besides protein, what other molecuels could be antigens?
- Carbohydrates and polysaccharides
- –a. lipopolysaccharide
- –b. capsular dextran - Lipids
- Nucleic acids
Carbohydrates and polysaccharides as antigen usually induce?
a. lipopolysaccharide- usually induce IgM
b. capsular dextran- usually induce IgM
