mt.2 Antigen Antibody Lec 6 (IgA, M, E, D)

Question 1

what immunoglobulin is in the highest concentrations in secretions?

Answer 1

IgA

Question 2

How big is IgA in blood and secretions?

Answer 2

Molecular weight 150,000 daltons in blood/300,000 daltons in secretions

Question 3

what are the sub-classes of IgA?

Answer 3

two sub-classes: IgA1, IgA2

Question 4

Monomeric or dimeric IgA in blood? in secretions?

Answer 4

• blood= Monomeric (2 antigen binding sites)

* secretions= Dimeric (4 antigen binding sites)

Question 5

IgA can or cannot fix complement?

Answer 5

canNOT

Question 6

IgA can or cannot cross placenta?

Answer 6

canNOT

Question 7

IgA prevents adherence of microbes where?

Answer 7

at secretory surfaces of oral cavity, lung, nasal cavity, eyes, gastrointestinal tract, genitourinary tract

Question 8

Where is IgA secreted?

Answer 8

In the salivary gland, beneath the ductal epithelium lie plasma cells that secrete dimeric IgA

Question 9

What immunoglobulin has the highest molecular weight?

Answer 9

IgM at 900,000daltons

Question 10

what are the sub-classes of IgM?

Answer 10

there are none. ONE CLASS

Question 11

what is the shape of IgM?

Answer 11

pentameric

Question 12

what does IgM being pentameric mean?

Answer 12

ten antigen binding sites

Question 13

IgM can or cannot fix complement?

Answer 13

CAN

Question 14

what immunoglobulins can fix complement?

Answer 14

IgG and IgM

Question 15

IgM is first produced during?

Answer 15

primary immune response

Question 16

Monomeric or pentameric IgG in secretions? at cell surface?

Answer 16

• secreted= pentameric

* cell surface= monomeric

Question 17

what immunoglobulin is the reaginic antibody?

Answer 17

IgE

Question 18

what is the last immunoglobulin dicovered?

Answer 18

IgE

Question 19

IgE is found in higher concentration in poeple with?

Answer 19

allergies (low otherwise)

Question 20

what are the sub-classes of IgE?

Answer 20

there are none. ONE CLASS

Question 21

IgE can or cannot fix complement?

Answer 21

canNOT

Question 22

IgE can or cannot enhance phagocytosis?

Answer 22

canNOT

Question 23

IgE can or cannot bind to histamine rich

basophils or mast cells?

Answer 23

can

Question 24

How do IgE bind to bind to histamine rich

basophils or mast cells?

Answer 24

via Fc-Epsilon receptors that bind to the Fc region

Question 25

what are the sub-classes of IgE?

Answer 25

there are none. ONE CLASS

Question 26

What immunoglobulins have only ONE class?

Answer 26

IgM, IgE, IgD

Question 27

Does IgD have high or low populations in blood?

Answer 27

low

Question 28

IgD is only found on the surface of?

Answer 28

mature B cells

Question 29

If IgD is only found on the surface of mature B cells, how is there Free IgD in the blood?

Answer 29

probably sheared off of B cells to get into blood

Question 30

IgD is NOT made by what type of cell?

Answer 30

plasma cells