5.2 Cells N Tissues Adapt Immunity Spleen

Question 1

Spleen is another secondary lymphoid organ where antigen enters from?

Answer 1

the blood stream via the central arteriole of the spleen

Question 2

Spleen has ___ and ____ pulp?

Answer 2

red and white pulp

Question 3

red pulp of spleen is populated with?

Answer 3

with red blood cells, macrophages, and plasma cells

Question 4

white pulp of spleen is populated with?

Answer 4

with lymphocytes that generate an immune response

*where we have follicles in spleen

Question 5

Spleen has follicles along the?

Answer 5

central arterioles

Question 6

T cell area of spleen adjacent to the central arteriole is the?

Answer 6

periarteriole lymphoid sheath

Question 7

B cell area with germinal centers of spleen are in the center of the T cell area but?

Answer 7

separate

Question 8

plasma cells migrate to the?

Answer 8

red pulp and bone marrow

Question 9

Common mucosal immune system provide immunity to?

Answer 9

mucosal surfaces

Question 10

Common mucosal immune system mucosal surfaces are constantly exposed to?

Answer 10

to the environment, including microbes

Question 11

Compare # of lymph nodes vs spleen

Answer 11

Hundreds of lymph nodes

*typically onely ONE spleen

Question 12

What is BALT?

What is GALT?

Answer 12

• Bronchus associated lymphoid tissue
• Gut associated lymphoid tissue
• **BOTH are branches of common mucosal immune system

Question 13

Immunity at one point in the GALT or BALT tissue is shared by?

Answer 13

all points in these tissue

Question 14

Adaptive immunity-the GALT pathway?

**KNOW

Answer 14

1) M cells of Peyer’s patches of the Ileum
2) Follicles of Peyer’s patches
3) Mesenteric lymph nodes
4) Thoracic duct lymph
5) Blood circulation
6) Spleen
7) Circulation
8) salivary gland, lamina propria, lacrimal gand, mammary gland, genito/urinary tract

Question 15

Where are Peyer’s patches found?

Answer 15

found along the small intestine (ileum) ~400

Question 16

Each Peyer’s patche has a dome of cells with?

Answer 16

T and B cells mixed together

Question 17

What is below the dome of cells in Peyer’s patches?

Answer 17

every dome of cells has follicles containing B cells (mostly) in it

Question 18

In Peyer’s Patches, the B cell follicles have?

Answer 18

germinal center with ongoing immune response

Question 19

Where are T-cells located in Peyer’s Pathces?

Answer 19

1) perifollicular area contains T cells except

2) some T cells are in the germinal center

Question 20

B cells in intestine that are going to become plasma cells migrate out of?

Answer 20

Peyer’s patches via the GALT pathway

Question 21

once B cells migrate out Peyer’s Patchs and become plasma cells, where do they go?

Answer 21

end up in the salivary gland, lacrimal (tears) gland, lamina propria of small intestine or any other mucosal secretory sites

Question 22

Microfold (M) cells are a type of _____ cell

Answer 22

epithelial

Question 23

Microfold (M) cells present or found where?

Answer 23

among the villous epithelium of the small intestine

Question 24

Each M-cell is vigorous in _____ and _____

Answer 24

phagocytosis and transcytosis

Question 25

Microfold (M) cells uptake what? Then do what?

*main function?!?

Answer 25

luminal antigens such as bacteria. Then deliver the antigens to the immune cells in GALT for initiation of gut immune response
*CAPTURE stuff via phagocytosis and transcytosis

Question 26

M cells are not covered by?

Answer 26

mucous layer 
(makes them more susceptible to pathogens= good and bad thing)

Question 27

What is ‘interesting’ about GALT and BALT?

Answer 27

they are the initial cites for immune responses BUT the END points for the effector antibodies that are coming out (meaning the information coming from either is shared at all the different cites of the body)

Question 28

99% of B plasma cells in GALT system are making what antibody?

Answer 28

IgA