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Flashcards in Acid-Controlling Drugs Deck (20):
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Cimetidine (Tagamet)
(Functional Classification)

H2-histamine receptor antagonist

1

Cimetidine (Tagamet)
(Chemical Classification)

Imidazole Derivative

2

Cimetidine (Tagamet)
(Mechanism of Action)

Inhibits histamine at H2-receptor site in the gastric parietal cells, which inhibits gastric acid secretion

3

Cimetidine (Tagamet)
(Uses)

Short-term treatment of duodenal and gastric ulcers and maintenance; management of GERD (PO) and Zollinger-Ellison syndrome; prevention of upper GI bleeding; prevent, relieve heartburn, acid indigestion, upper GI bleeding

4

Cimetidine (Tagamet)
(Contraindications)

Hypersensitivity

5

Cimetidine (Tagamet)
(Side Effects)

CNS: Constipation, Headache, depression, dizziness, anxiety, weakness, psychosis, tremors, SEIZURES
CV: bradycardia, tachycardia, DYSRHYTHMIAS
GI: Diarrhea, abdominal cramps, PARALYTIC ILEUS, JAUNDICE
GU: gynecomastia, galactorrhea, impotence, increase in BUN, creatinine
HEMA: AGRANULOCYTOSIS, THROMBOCYTOPENIA, NEUTROPENIA, APLASTIC ANEMIA, INCREASE IN PT
INTEG: urticaria, rash, alopecia, sweating, flushing, EXFOLIATIVE DERMATITIS
RESP: PNEUMONIA

6

Cimetidine (Tagamet)
(Nursing Considerations)

ASSESS:
-Gastric pH(>/=5 should be maintained); epigastric pain, duration, intensity; aggravating, ameliorating factors
-I&O ratio, BUN, creatinine, LFTs, CBC with differential periodically

7

Famotidine (Pepcid)
(Functional Classification)

H2-histamine receptor antagonist

8

Famotidine (Pepcid)
(Mechanism of Action)

Competitively inhibits histamine at histamine H2-receptor site, thus decreasing gastric secretion while pepsin remains at a stable level

9

Famotidine (Pepcid)
(Uses)

Short-term treatment of active duodenal ulcer, maintenance therapy for duodenal ulcer, Zollinger-Ellison syndrome, multiple endocrine adenomas, gastric ulcers; gastroesophageal reflux disease, heartburn

10

Famotidine (Pepcid)
(Contraindications)

Hypersensitivity

11

Famotidine (Pepcid)
(Side Effects)

CNS: Headache, Dizziness, paresthesia, depression, anxiety, somnolence, insomnia, fever, SEIZURES IN RENAL DISEASE
CV: DYSRHYTHMIAS, QT PROLONGATION (IMPAIRED RENAL FUNCTIONING)
EENT: taste change, tinnitus, orbital edema
GI: Constipation, nausea, vomiting, anorexia, cramps, abnormal hepatic enzymes, diarrhea
HEMA: THROMBOCYTOPENIA, APLASTIC ANEMIA
INTEG: rash, TOXIC EPIDERMAL NECROLYSIS, STEVENS-JOHNSON SYNDROME
MS: myalgia, arthralgia
RESP: PNEUMONIA

12

Famotidine (Pepcid)
(Nursing Considerations)

ASSESS:
-ULCERS: epigastric pain, abdominal pain, frank or occult blood in emesis, stools
-Intragastric pH, serum creatinine/BUN baseline and periodically
-Blood counts during therapy; watch for decreasing platelets; if low, therapy may have to be discontinued, restarted after hematologic recovery
-For bleeding, hematuria, hematuresis, occult blood in stools; abdominal pain
-BLOOD DYSCRASIAS (THROMBOCYTOPENIA): bruising, fatigue, bleeding, poor healing

PERFORM/PROVIDE:
-Increase in bulk and fluids in diet to prevent constipation

13

Sucralfate
(Functional Classification)

Protectant, antiulcer

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Sucralfate
(Chemical Classification)

Aluminum hydroxide, sulfated sucrose

15

Sucralfate
(Mechanism of Action)

Forms a complex that adheres to ulcer site, absorbs pepsin

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Sucralfate
(Uses)

Duodenal ulcer, oral mucositis, stomatitis after radiation of head and neck

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Sucralfate
(Contraindications)

Hypersensitivity

18

Sucralfate
(Side Effects)

CNS: drowsiness, dizziness
GI: Dry Mouth, Constipation, nausea, gastric pain, vomiting, bezoar (for critically ill patients)
INTEG: urticaria, rash, pruritus

19

Sucralfate
(Nursing Considerations)

ASSESS:
-GI SYMPTOMS: abdominal pain, blood in stools
-HYPOGLYCEMIA: may occur in patients with diabetes mellitus