Antitubercular Drugs Flashcards Preview

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Flashcards in Antitubercular Drugs Deck (15):
0

Isoniazid
(Functional Classification)

Antitubercular

1

Isoniazid
(Chemical Classification)

Isonicotinic acid hydrazide

2

Isoniazid
(Mechanism of Action)

Bactericidal interference with lipid, nucleic acid biosynthesis

3

Isoniazid
(Uses)

Treatment, prevention of TB

4

Isoniazid
(Contraindications)

Hypersensitivity
Acute Hepatic Disease

5

Isoniazid
(Side Effects)

CNS: Peripheral Neuropathy, Dizziness, memory impairment, TOXIC ENCEPHALOPATHY, SEIZURES, psychosis, slurred speech
EENT: blurred vision, optic neuritis
GI: Nausea, Vomiting, epigastric distress, JAUNDICE, FATAL HEPATITIS
HEMA: AGRANULOCYTOSIS, HEMOLYTIC, APLASTIC ANEMIA, THROMBOCYTOPENIA, EOSINOPHILIA, METHEMOGLOBINEMIA
HYPERSENSITIVITY: fever, skin eruptions, lymphadenopathy, vasculitis
MISC: Dyspnea, B6 deficiency, pellagra, hyperglycemia, metabolic acidosis, gynecomastia, rheumatic syndrome, SLE-like syndrome

6

Isoniazid
(Nursing Considerations)

ASSESS:
-Hepatic studies weekly: ALT, AST, bilirubin; increased test results may indicate hepatitis; hepatic status: decreased appetite, jaundice, dark urine, fatigue
-mental status often: affect, mood, behavioral changes; psychosis may occur
-paresthesia in hands, feet

7

Isoniazid
(Overdose Treatment)

Pyridoxine

8

Rifampin
(Functional Classification)

Antitubercular

9

Rifampin
(Chemical Classification)

Rifamycin B derivative

10

Rifampin
(Mechanism of Action)

Inhibits DNA-dependent polymerase, decreases tubercle bacilli replication

11

Rifampin
(Uses)

Pulmonary TB, meningococcal carriers (prevention)

12

Rifampin
(Contraindications)

Hypersensitivity to this product, rifamycins; active Neisseria meningitidis infection

13

Rifampin
(Side Effects)

CNS: headache, fatigue, anxiety, drowsiness, confusion
EENT: visual disturbances
GI: Nausea, Vomiting, Anorexia, Diarrhea, PSEUDOMEMBRANOUS COLITIS, Heartburn, sore mouth and tongue, PANCREATITIS, increased LFTs
GU: HEMATURIA, ACUTE RENAL FAILURE, HEMOGLOBINURIA
HEMA: HEMOLYTIC ANEMIA, ANEMIA, EOSINOPHILIA, THROMBOCYTOPENIA, LEUKOPENIA
INTEG: rash, pruritus, urticaria
MISC: flulike symptoms, menstrual disturbances, edema, SOB, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, ANGIEDEMA, ANAPHYLAXIS
MS: ataxia, weakness

14

Rifampin
(Nursing Considerations)

ASSESS:
-INFECTION: sputum culture, lung sounds, characteristics of sputum
-Signs of anemia: Hct, Hgb, fatigue
-Hepatic studies monthly: ALT, AST, bilirubin
-Renal status before, each mo: BUN, creatinine, output, specific gravity, urinalysis
-Hepatic status: decreased appetite, jaundice, dark urine, fatigue
-SERIOUS SKIN REACTIONS: fever, sore throat, fatigue, ulcers; lesions in mouth, lips, rash; can be fatal
-PSEUDOMEMBRANOUS COLITIS: diarrhea, fever, abdominal pain/cramping, bloody stools, product should be discontinued, prescriber notified