Antiparkinson Drugs Flashcards Preview

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Flashcards in Antiparkinson Drugs Deck (14):
0

Carbidopa-Levodopa
(Functional Classification)

Antiparkinson agent

1

Carbidopa-Levodopa
(Chemical Classification)

Catecholamine

2

Carbidopa-Levodopa
(Mechanism of Action)

Decarboxylation of levodopa in periphery is inhibited by carbidopa; more levodopa is made available for transport to the brain and for conversion to dopamine in the brain

3

Carbidopa-Levodopa
(Uses)

Parkinson's disease, parkinsonism resulting from carbon monoxide, chronic manganese intoxication, cerebral arteriosclerosis

4

Carbidopa-Levodopa
(Contraindications)

Hypersensitivity, malignant melanoma, history of malignant melanoma or undiagnosed skin lesions resembling melanoma

5

Carbidopa-Levodopa
(Side Effects)

CNS: Involuntary Choreiform Movements, Hand Tremors, Fatigue, Headache, Anxiety, Twitching, Numbness, Weakness, Confusion, Agitation, Insomnia, Nightmares, psychosis, hallucination, hypomania, severe depression, dizziness, impulsive behaviors, NEUROLEPTIC MALIGNANT SYNDROME
CV: Orthostatic Hypotension, tachycardia, hypertension, palpitation
EENT: blurred vision, diplopia, dilated pupils
GI: Nausea, Vomiting, Anorexia, Abdominal Distress, Dry Mouth, Flatulence, Dysphagia, bitter taste, diarrhea, constipation
HEMA: HEMOLYTIC ANEMIA, LEUKOPENIA, AGRANULOCYTOSIS
INTEG: rash, sweating, alopecia
MISC: urinary retention, incontinence, weight change, dark urine

6

Carbidopa-Levodopa
(Nursing Considerations)

ASSESS:
-PARKINSON'S SYMPTOMS: tremors, pill rolling, drooling, akinesia, rigidity, shuffling gait before, during treatment, BP, respiration; orthostatic BP
-Mental Status: affect, mood, behavioral changes, depression, complete suicide assessment
-Toxicity: muscle twitching, blepharospasm
-Renal, hepatic, hematopoietic tests; also for diabetes, acromegaly if on long-term therapy

7

Ropinirole (Requip)
(Functional Classification)

Antiparkinson agent

8

Ropinirole (Requip)
(Chemical Classification)

DOPamine-receptor agonist, nonergot

9

Ropinirole (Requip)
(Mechanism of Action)

Selective agonist for D2 receptors (presynaptic/postsynaptic sites); binding at D3 receptor contributes to antiparkinson effects

10

Ropinirole (Requip)
(Uses)

Parkinson's disease, restless leg syndrome (RLS)

11

Ropinirole (Requip)
(Contraindications)

Hypersensitivity

12

Ropinirole (Requip)
(Side Effects)

CNS: Agitation, Insomnia, psychosis, hallucination, dystonia, depression, dizziness, somnolence, SLEEP ATTACKS, impulse control disorders
CV: Orthostatic Hypotension, tachycardia, hypo/hypertension, syncope, palpitations
EENT: blurred vision
GI: Nausea, Vomiting, Anorexia, Dry Mouth, constipation, dyspepsia, flatulence
GU: impotence, urinary frequency
HEMA: HEMOLYTIC ANEMIA, LEUKOPENIA, AGRANULOCYTOSIS
INTEG: rash, sweating
RESP: pharyngitis, rhinitis, sinusitis, bronchitis, dyspnea

13

Ropinirole (Requip)
(Nursing Considerations)

ASSESS:
-PARKINSONISM: akinesia, tremors, staggering gait, muscle rigidity, drooling
-BP, respirations during initial treatment; hypo/hypertension should be reported
-SLEEP ATTACKS: drowsiness, falling asleep without warning even during hazardous activities
-Mental status: affect, mood, behavioral changes, depression; complete suicide assessment; worsening of symptoms in restless leg syndrome

PERFORM/PROVIDE:
-Testing for diabetes mellitus, acromegaly if patient receiving long-term therapy