CNS Stimulants and Related Drugs Flashcards Preview

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Flashcards in CNS Stimulants and Related Drugs Deck (15)
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0
Q

Methylphenidate (Ritalin)

Chemical Classification

A

Piperdine derivative

1
Q

Methylphenidate (Ritalin)

Functional Classification

A

Cerebral Stimulant

2
Q

Methylphenidate (Ritalin)

Mechanism of Action

A

Increases release of norepinephrine, dopamine in cerebral cortex to reticular activating system; exact action not known

3
Q

Methylphenidate (Ritalin)

Uses

A

Attention Deficit Disorder (ADD), attention-deficit/hyperactivity disorder (ADHD); narcolepsy (except Concerta, Metadate CD, Ritalin LA)

4
Q

Methylphenidate (Ritalin)

Contraindications

A

Children s syndrome; glaucoma, anorexia nervosa, tartrazine dye hypersensitivity

5
Q

Methylphenidate (Ritalin)

Side Effects

A

CNS: Hyperactivity, Insomnia, Restlessness, Talkativeness, dizziness, drowsiness, toxic psychosis, headache, akathisia, dyskinesia, masking or worsening of Gilles de la Tourette’s syndrome, SEIZURES, hallucinations, MALIGNANT NEUROLEPTIC SYNDROME, aggression; CEREBRAL VASCULITIS, HEMORRHAGE, STROKE (RARE)
CV: Palpitations, Tachycardia, BP changes, angina, DYSRHYTHMIAS
ENDO: growth retardation
GI: nausea, anorexia, dry mouth, weight loss, abdominal pain
HEMA: LEUKOPENIA, ANEMIA, THROMBOCYTOPENIC PURPURA
INTEG: EXFOLIATIVE DERMATITIS, urticaria, rash, erythema multiforme, HYPERSENSITIVITY REACTIONS
MISC: fever, arthralgia, scalp hair loss

6
Q

Methylphenidate (Ritalin)

Nursing Considerations

A

ASSESS:

  • ADHD: attention span, decreased hyperactivity
  • VS, BP; may reverse antihypertensives; check patients with cardiac disease more often for increased BP
  • CBC with differential, platelets, LFTs, urinalysis; in diabetes: blood glucose, urine glucose; insulin changes may have to be made because eating will decrease
  • Height, growth rate q3mo in children; growth rate may be decreased
  • Mental status: mood, sensorium, affect, stimulation, insomnia, aggressiveness
  • WITHDRAWAL SYMPTOMS: headache, nausea, vomiting, muscle pain, weakness
  • Appetite, sleep, speech patterns
  • NARCOLEPSY: identify frequency, length of narcoleptic episodes
7
Q

Methylphenidate (Ritalin)

Overdose Treatment

A

Administer fluids; hemodialysis or peritoneal dialysis; antihypertensive for increased BP; administer short-acting barbiturate before lavage

8
Q

Sumatriptan (Imitrex)

Functional Classification

A

Antimigraine Agent

9
Q

Sumatriptan (Imitrex)

Chemical Classification

A

5-HT1B/D receptor agonist, abortive agent, triptan

10
Q

Sumatriptan (Imitrex)

Mechanism of Action

A

Binds selectively to vascular 5-HT1B/D receptor subtype, exerts antimigraine effect; causes vasoconstriction in cranial nerves

11
Q

Sumatriptan (Imitrex)

Uses

A

Acute treatment of migraine with/without aura and cluster headache

12
Q

Sumatriptan (Imitrex)

Contraindications

A

Angina pectoris, history of MI, documented silent ischemia, Prinzmetal’s angina, ischemic heart disease, IV use, concurrent ergotamine-containing preparations, uncontrolled hypertension, hypersensitivity, basilar or hemiplegic migraine

13
Q

Sumatriptan (Imitrex)

Side Effects

A

CNS: Tingling, Hot Sensation, Burning, Feeling of Pressure, Tightness, Numbness, Dizziness, Sedation, headache, anxiety, fatigue, cold sensation
CV: Flushing, MI, hypo/hypertension
EENT: throat, mouth, nasal discomfort; vision changes
GI: abdominal discomfort
INTEG: Inj site reaction, sweating
MS: Weakness, Neck Stiffness, myalgia
RESP: chest tightness, pressure

14
Q

Sumatriptan (Imitrex)

Nursing Considerations

A

ASSESS:

  • MIGRAINE: type of pain, aura; alleviating, aggravating factors; sensitivity to light, noise
  • SEROTONIN SYNDROME: delirium, coma, agitation, diaphoresis, hypertension, fever, tremors; may resemble neuroleptic malignant syndrome in patients taking SSRIs, SNRIs
  • BP, signs, symptoms of coronary vasospasms, ECG
  • Tingling, hot sensation, burning, feeling of pressure, numbness, flushing, inj site reaction
  • Stress level, activity, reaction, coping mechanisms
  • Neurologic status: LOC, blurring vision, nausea, vomiting, tingling in extremities preceding headache
  • Ingestion of tyramine foods (pickled products, beer, wine, aged cheese), food additives, preservatives, colorings, artificial sweeteners, chocolate, caffeine, which may precipitate these types of headaches
  • Renal function, urine output

PERFORM/PROVIDE
-Quiet, calm environment with decreased stimuli: noise, bright light, excessive talking