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Flashcards in Pituitary Drugs Deck (21):
0

Octreotide
(Functional Classification)

Growth Hormone, antidiarrheal

1

Octreotide
(Chemical Classification)

Synthetic Octapeptide

2

Octreotide
(Mechanism of Action)

A potent growth hormone similar to somatostatin

3

Ocreotide
(Uses)

Sandostatin: acromegaly, improves symptoms of carcinoid tumors, vasoactive intestinal peptide tumors (VIPomas)
LAR Depot: long-term maintenance of acromegaly, carcinoid tumors, VIPomas

4

Octreotide
(Contraindications)

Hypersensitivity

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Octreotide
(Side Effects)

CNS: Headache, Dizziness, Fatigue, Weakness, depression, anxiety, tremors, SEIZURE, paranoia
CV: Sinus Bradycardia, Conduction Abnormalities, DYSRHYTHMIAS. chest pain, SOB, thrombophlebitis, ischemia, CHF, hypertension, palpitations, QT PROLONGATION, ST- OR T-WAVE CHANGES
ENDO: Hypo/Hyperglycemia, Ketosis, Hypothyroidism, galactorrhea, diabetes insipidus
GI: Diarrhea, Nausea, Abdominal Pain, Vomiting, Flatulence, Distention, Constipation, HEPATITIS, increased LFTs, GI BLEEDING, PANCREATITIS, cholelithiasis, ileus
GU: UTI
HEMA: hematoma of inj site, bruise
INTEG: rash, urticaria, pain; inflammation at inj site
MS: Joint and Muscle Pain

6

Octreotide
(Nursing Considerations)

ASSESS:
-Growth hormone antibodies, IGF-1 at 1- to 4-hr intervals for 8-12 hr after dose (ACROMEGALY); 5-HIAA, plasma serotonin; blood glucose, serotonin levels (CARCINOID TUMORS), plasma substance P, plasma vasoactive intestinal peptide (VIP) (VIPoma)
-Thyroid function tests: T3, T4, T7, TSH to identify hypothyroidism
-Fecal fat, serum carotene
-ALLERGIC REACTION: rash, itching, fever, nausea, wheezing
-CARDIAC STATUS: bradycardia, conduction abnormalities, dysrhythmias; monitor ECG for QT prolongation, low voltage, axis shifts, early repolarization, R/S transition, early wave progression

7

Somatropin
(Functional Classification)

Pituitary hormone

8

Somatropin
(Chemical Classification)

Growth Hormone

9

Somatropin
(Mechanism of Action)

Stimulates growth; somatropin is similar to natural growth hormone; both preparations were developed with the use of recombinant DNA

10

Somatropin
(Uses)

Pituitary growth hormone deficiency (hypopituitary dwarfism), children with human growth hormone deficiency/growth failure, AIDS wasting syndrome, cachexia, adults with somatropin deficiency syndrome (SDS), short stature in Noonan syndrome, SHOX deficiency, Turner's syndrome, Prader-Willi syndrome

11

Somatropin
(Contraindications)

Hypersensitivity to benzyl alcohol, creosol; closed epiphyses, intracranial lesions, acute respiratory failure, Prader-Willi syndrome with obesity, trauma

12

Somatropin
(Side Effects)

CNS: headache, growth of intracranial tumor, fever, aggressive behavior
ENDO: hyperglycemia, ketosis, hypothyroidism
GI: nausea, vomiting
GU: Hypercalciuria
INTEG: rash, urticaria, pain; inflammation at inj site, hematoma
MS: tissue swelling, joint and muscle pain
SYST: ANTIBODIES TO GROWTH HORMONE

13

Somatropin
(Nursing Considerations)

-Signs/symptoms of diabetes
-Growth hormone antibodies if patient fails to respond to therapy
-Thyroid function tests: T3,T4,T7, TSH to identify hypothyroidism
-ALLERGIC REACTION: rash, itching, fever, nausea, wheezing
-HYPERCALCIURIA: urinary stones; groin, flank pain; nausea, vomiting, urinary frequency, hematuria, chills
-Growth rate, bone age of child at intervals during treatment

14

Vasopressin
(functional Classification)

pituitary hormone

15

Vasopressin
(Chemical Classification)

Lysine, Vasopressin

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Vasopressin
(Mechanism of Action)

Promotes the reabsorption of water via action on the renal tubular epithelium; causes vasoconstriction

17

Vasopressin
(Uses)

Diabetes insipidus (nonnephrogenic/nonpsychogenic), abdominal distention postoperatively, bleeding esophageal varices

18

Vasopressin
(Contraindications)

Hypersensitivity, chronic nephritis

19

Vasopressin
(Side Effects)

CNS: drowsiness, headache, lethargy, flushing, vertigo
CV: increased BP, dysrhythmias, CARDIAC ARREST, SHOCK, chest pain, MI
EENT: nasal irritation, congestion, rhinitis
GI: nausea, heartburn, cramps, vomiting, flatus
GU: vulval pain, uterine cramping
MISC: tremor, sweating, vertigo, urticaria, bronchial constriction

20

Vasopressin
(Nursing Considerations)

ASSESS:
-Pulse, BP when giving product IV or IM
-I& ratio, weight daily; fluid/electrolyte balance; check for edema in extremities; if water retention is severe, diuretic may be prescribed
-WATER INTOXICATION: lethargy, behavior changes, disorientation, neuromuscular excitability
-Small doses may precipitate coronary adverse effects; keep emergency equipment nearby