anti-fungal drugs Flashcards Preview

GI > anti-fungal drugs > Flashcards

Flashcards in anti-fungal drugs Deck (51):
1

MOA of flucyosine

inhibits fungal nucleic acid by interfereing with fungal thymidylate

2

MOA of griseofulvin

inhibits mitosis by binding to tubilin

3

Polyenes MOA

destabylizes fungal membrane

4

drugs that inhibit squalene expoxidase

allyl- and benzyl-amines

5

drugs that inhibit 14 alpha demethylase

Tri-, imid-azoles

6

MOA of echinocandins

inhibits cell wall synthesis

7

can cause bone marrow suppression

flucytosine

8

use of flucytosine

used with Ampotercin B to treat systemic candida and cyptococcal infections

9

accumultes in keratin precursor cells

griseofulvin,

10

use of griseofulvin

syperficial mycoses

11

must be used for 6 months to a year

griseofulvin

12

SE of griseofulvin

headache, hepatic enzyme induction , and disulfrim reactions

13

MOA of terbinafine and butenafine

prevent formation of lanosterol by squalene epoxidase inhibition, and produce accumulation of toxic squalene metabolite

14

accumulates in hair, skin and nails

terbinafine

15

cures most nail mycoses

terbinafine

16

SE of terbinafine

GI upset, headache, rare hepatic toxicity

17

300 hr half life drug

terbinafine

18

use of butenafine

superficial mycoses

19

-azole MOA

inhibit 14a demathylase, decreasing ergosterol formation and increasing accumulation of toxic 14a-methyl sterole

20

inhibits hepatic P450 and can cause drug interactiions

-azole

21

broad spectrum fungistatic at low doses, fungicidal at high doses

-azole

22

SE of ketoconazole

inhibiton of P450 n/v, endocrine abnormalities

23

DOC for systemic blastomyces, sporothix, and SQ chromoblastomycosis

itraconazole

24

azoles that do not cross the BBB

intra, keto,

25

azoles that DO cross BBB

fluco

26

used as a single dose for vaginal candida

fluconazole

27

absorption not effected by gastric pH

fluconazole

28

used for phrolylaxis of crytococcal meningitis

fluconazole

29

DOC for esophgeal and oropharyngel candidasis

fluconazole

30

only azole used for mucormycosis

posaconazole

31

DOC for invasic aspergillosis

vericonazole

32

can cause visual disturbances

vericonazole

33

inhibits CYP3A4

posaconazole

34

form of posacanzole

oral

35

broadest spectrum -azole

posaconazole

36

topical OTC -azoles with significant systemic toxicity

clotrimazole and miconazole

37

DOC for serious systemic mycosis

amphotericin

38

MOA of amhpotericin B

binds to fungal erosterol to form a pore, distrupting membrane stability

39

reason amphotericin B has low toxicity

affinity is 500 times higher for fungal erosterol than human

40

does amphotercin B cross the BBB?

no

41

way amphocerterin must be administered

IV (highly insolulabe)

42

dose related SE of amphotericin

kidney damage, anemia

43

infusion related SE of amphotericin

fever, chills, muscle spasma, vomiting, hypotension

44

way to treat infusion related SE of amphotericin

infuse slowly or pretreat with antihistamines

45

formulation of ampotericin B that reduces toxity

lipid formulation

46

MOA of echinocandins

target fungal cell wall sythesis

47

caspofungin class

echinocandins

48

use of caspofungin

IV for esophageal candiadis and spergillus

49

used IV for esiphageal and invasive candidias

anidulafungin

50

used Iv for mucocutaneous candidiadsis and prophalyxis for candida in BM transplant pts

micofungin

51

can produce histamine release and flushing

micofungin and echinocandins