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Flashcards in anti emetics Deck (23):
1

efferent pathway of n/v

vomiting center --> nucleus tractus solitarious --> cranial nerves to M1, H1 D2 serotinin receptors

2

location of vomiting center

lateral medullary reticular formation

3

afferent inputs ti vomitingc center

chemorecptor in area postrema
vestibular system via CN VIII
gag reflex via CN X
5 HT receptors in GI mucosa
cerebral cortex

4

ondansetron, granisetron, dolasetron

5-HT3 antagonists

5

5-HT3 antagonists action restricted to

emesis casued by vagal stimulation

6

use of 5-HT3 antagonosts

acute chemo, surgery, radiation induced vomiting

7

5-HT3 antagonosts metabolism

hepatic

8

5-HT3 antagonosts SE

headache, dizzinness, constipation

9

metoclpramide MOA

D2 receptor antagonists

10

metoclopramide SE

extrpyramidal effectes, restlessness, dystonia

11

prochloroperazine MOA

inhibition of dopaminergic, muscarinuc and histaminergic receptors

12

seditive antiemetic

prochloroperazine, droperidol

13

antipsychotic and sedative antiemetic

droperidol

14

can cause hypotension

droperidol

15

MOA of droperidol

central sopaminergic blockade

16

SE of antihistamines

sedation, dizziness, confusion, dry mouth

17

H1 antihistamnes used for nausea

meclixine, promethazine

18

H1 antihistamine used for motion sickness and vertigi

meclizine

19

DOC for motion sickness

scopalamine

20

cannabanoid antiemetic

dronabinil

21

SE of dronabinol

euphoria, sedation, hallucinations, increased appatite (may be desired effect)

22

aprepitant MOA

blocks substance P in vomiting center

23

used to prevent anticipatory vomiting before chemo

benzos