anti helminthic/protozoal drugs Flashcards Preview

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Flashcards in anti helminthic/protozoal drugs Deck (51):
1

Drugs against nematodes (roundworms)

albendazole
Diethylcarbamazine
ivermectin
mebendazole
pyrantel

2

drugs active against tremadotes (flukes)

praziquentel
bithionol
metrifonate
oxaniquine

3

drugs against cestodes (tapeworms)

nilosamine
praziquentel
albendazole
mebendazole

4

DOC for tapeworms

niclosamide

5

MOA of niclosamide

uncoupling of oxidasive phosphorylation, or by activating ATPases

6

result of niclosamide

detachment of bug from intestinal wall and evacuation

7

SE of niclosamide

slight abdominal discomfort

8

niclosamide will not work on

ova

9

way to remove tapeworm ova from GI

purging of tract, drugs will not usually kill

10

DOC for cestode AND trematode

praziquantil

11

MOA of praziquantil

increases permability of worm cell membrane to Ca++ ions.

12

results of praziquantil

massive contracture of worm body and impairs it's ability to attach to intestinal wall

At high doses, can activate host immune reponse

13

SE of V

abdominal discomfort, fever, sedation, headache

14

anti-hemlith that has extensive first-pass metabilism

praziquantil

15

DOC for roundworms

-dazoles

16

very wide spectrum -dazole (nematodes and cestodes)

albendazole

17

MOA of albendazole

larvicidal effect due to inhibition of microtubule activity

18

SE of albendazole

reversible leukopenia, alopecia, eleveted liver enzymes, bone marrrow suppression in LTT

19

DOC for most GI nematodes

mebendazole

20

MOA for mebendazole

inhibition of hemlitnth glucose uptake, inhibition of microtuble polymerization

21

drug that lethal effect extends to adults and ova

mebendazole

22

DOC for pinworms

mebendazole

23

drug given to all household members

mebendazole for pinworm

24

SE of mebendazole

abdominal disomfort, diarrhea

25

why does mebendazole have a large conentration in the colon

very poorly absorbed by SI

26

contraindicated in pregancy

mebendazole, pyrantel pamoate, metronidazole

27

ALt drug for nematodes

thiabendazole

28

MOA for thiabendazole

inhibition of glucose uptake, AND inhibition of fumarate reductase (needed for anaerobic metabolism)

29

larve that are not affected by thiabendazole

trichnella spiralis (porkworm) in muscle

30

causes stevens-johnson syndrome

thiabendazole

31

SE of thiabendazole

N/V, diarrhea, vertigo, crystalluria, leukopenia, SSJ

32

major use for thiabendazole

creeping skin eruptions with strongylodies sercoralis

33

DOC for hookworm and roundworm

pyrantel pamoate

34

MOA of pyrantel pamoate

depolarises the myneural junction of helmith muscle

35

results of pyrantel pamoate

spastic paralysis in porkworm

36

SE of pyrantel pamoate

GI sx, fever, CNS effects

37

contraindicated in kids less than 1 yr of age

pyrantel pamoate

38

used with pyrantel pamoate

piperazine

39

use of piperazine

Alt drug for nematodes

40

contraindications of piperazine

epilepsy

41

DOC for O vululus (river blindness) and S stercoralis (threadworm)

mectizan

42

treatment for urinary shistosomiasis in africa

metrifonate

43

DOC for sheep liver fluke

bithionol

44

DOC for trichomoniasis, SI and Hepatic amebiasis and giardiasis

metronidazole

45

MOA of metronidazole

functions as electron sink in protazoa, ROS then disrupts DNA

46

contraindications of metronidazole

alchohol use, CNS disease, preggers

47

IV or sub Q alt drug for amebiasis

emetine and dehydroememtine

48

used for acute chagas

nifurtimox

49

DOC for leishmaniasis

sodium stibogluconate

50

onlyeffective drug for crypto

nitazoxanide

51

MOA of nitazoxanide

interferes with pyruvate enzyme deoendant electron transfer