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Flashcards in liver labs Deck (43):
1

test for intact liver synthesis

albumin
PT
INR

2

why is albumin not a good indicator for acute liver disease

albumin has a long half life

3

protein and albumin in liver disease will be:

low

4

non-hepatic causes of hypoalbuminia

protein malnutrition
nephrotic syndrome
severe burns

5

PT test result in liver damage

prolonged

6

why is PT test good for acutre liver damage

PT will respond within 24 hours of insult

7

PT used for

reye's, acetominaphen OD, acute EtOH hepatitis

8

can also prolong PT

vitamin K deficincy

9

if hepatocytes are not synthesising properly then:

albumin will be low, PT and INR will be long

10

albumin 1.5 indicates

severe, end stage liver disease

11

lest for hepatocyte injury

AST, ALT, LD, GGT

12

test for liver metabolic function

ammonia

13

elevation of AST withOUT ALT indicates

cardiac or muscle disease

14

most specific liver enzyme test

ALT

15

500-1000 ALT indicates

acute viral hep
ischemic hep
acute toxic liver injury
autoimmune hepatitis

16

ALT and AST 10x the normal range ALMOST ALWAYS indicate

severe direct hepatocyte damage

17

highly suggestive of alchoholic hepatitus

AST:ALT greater than 2

18

tests of biliary excretory function and obstruction of bile flow

elevated ALP, GGT, and bilirubin

19

elevated alkaline phosphatase is elevated in thee non-sick people

pregnant women

20

alkaline phoshatase 10x normal level can mean

extra-hepatobiliary obstruction

21

extra-hepatobiliary obstruction can be caused by

common bile duct obstruction or pancreatic cancer

22

Their major use is to determine if an elevated ALP is of hepatic etiology

GGT

23

in normal people, almost all bilirubin is

unconjugated

24

jaundice indicates elevated

bilirubin

25

hereditary unconjugated bilirubin

crigler-najjar sydrome

26

worst kind of crigler-najjar sydrome

type 1

27

mild jaundice with stress and illness

gilbert syndrome

28

conjugated bilirubin with all other normal liver functions intact

dubin-Johnson syndrome

29

possible causes of NEWBORN jaundice

ABO or RH immune mediated hemolysis

30

moderate/severe Rh hemolysis can cause

hydrops fetalis

31

deposition of unconjugated bilirubin in fetal brain

kernicturus

32

Markedly elevated unconjugated bilirubin?
Think

hemolysis

33

Markedly elevated conjugated bilirubin?
Think

hepatic injury or obstruction

34

primary test of pancreatic insuffeciency

fecal fat test

35

most common cause of acute pancreatitis

gallstones

36

more specific test for pancretitis

lipase

37

most common cause of chronic pancreatitis

EtOH

38

most COMMON test for pancreatitis

amylase

39

amalyse peaks at

12-72 hour

40

non pancreatitis cause of high amylase

IgG-Amylase Complexes

41

lipase peaks at

24 hours

42

can lead to increased lipase (non-pancreatitits)

pancreatic duct obstruction or renal impairment

43

non enzyme tests associated with acute pancreatitis

hyperTG, high hemocrit,