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Flashcards in antacids Deck (39):
1

how stomach acid is formed

1) meal, or anticipation of a meal relases gastrin
2) gastrin induces the release of histamin from ECL cells
3) histamine deffuses to paritel cells and acts on H2 receptors to produce cAMP
4) cAMP actiavtes the proton pump to secrete H+

2

acid protective factor released by epithelial cells

prostaglandin

3

recurrence rate of h pylori caused ulcers if the bug is not eliminated

100%

4

PPIs

-prazole

5

MOA of PPI

suicide inhibitor of H+/K+ pase

6

long acting antiacids

PPI

7

reason PPIs are long active

recovery requires sythethis of new enzyme and instertion into the cell membrane

8

requires an acidic environment for activation

PPI

9

cleared by hepatic metabolism

PPI

10

best taken before meals

PPI

11

inhibits CYP2C19 the least

pantoprazole

12

uses for PPI

1st line for GERD, best for peptic ulcers, ZOllinger-ellison

13

best drug for peptic ulcers

PPI

14

DOC for zollinger-ellison

PPI

15

potential serious side effect of PPI

bacterial bloom

16

drug intereaction with PPI

clopidogrel, ketoconazole, ampiclillin esters

17

drug regimen for H pylori

PPI+amoxicillin + clarithromycin (PAC)

18

H2 receptor antagonists

-tidine

19

uses for H2 receptor agonists

non-ulcer indigestion, duodenal ulcer, gastric ulcer, GERD

20

more effective antiacid

PPI

21

MOA of H2 RAs

inhibits secretion by gastrin and muscaric agonists. Inhibits basal and meal-induced gastric HCL secretion

22

decreases intrinsic factor production

H2 RA

23

absorbed by the SI

H2 RA

24

excreted unchanged by the kidney

H2 RA

25

requires reduction in H2 RA dose

H2 RA

26

has anti-nadrogenic effect

cimetdine

27

bismuth subcitrate/nitrate/salicylate

mucosal protocive agents

28

MOA of mucosal protocive agents

increase mucosal secretion, coats ulcer, detaches H pylori from gastric epithelium

29

sucralfate MOA

binds to and coats ulcer

30

SE of sucralfate

dry mouth, constipation

31

sucralafate decreases bioavailabllity of

tetracyline, phenytoin, digoxin, cimetidine

32

analog of PGE1

misoprostol

33

approved for NSAID induced ulcer

misoprostol

34

SE of misoprostol

smooth muscle exication (abdominal.uterine contraction)

35

SE of OTC antacids

kidney stones
hypernatremia
many drug interactions

36

Do NOT use sodium bicarb for

GERD, peptic ulcers

37

sometimes recommended to pregnant women

tums (CaCO3)

38

can cause diarrhea

milk of magnesia

39

can be constipating

Al compounds