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Flashcards in Antibiotics Deck (8):
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Streptomycin

Prevents binding of fmet-tRNA to prokaryotic ribosomes
Interferes with initiation of protein synth
Causes misreading of codons
Mutations in proteins associated with the small subunit can confer resistance or even dependence

1

Tetracylines

Inhibits binding of aminoacyl-tRNA's to mRNA-ribosome complex

2

Puromycin

analog of aminoacyl-tRNA
Binds to A-site. Stops chain elongation
Incomplete polypeptide chains formed with puromycin located on C-terminus
Works well in BOTH eukaryotes and prokaryotes

3

Erythromycin

Inhibits peptidyl transferase in prokaryotes

4

Cylcoheximide

Inhibits pepdityle transferase in EUKARYOTES

5

Ricin

Toxin (castor beans) attacks rRNA by removing adenine
Inactivates rRNA

6

Nalidixic Acid

Antibacterial (quinolone)
Inhibits DNA replication
Inhibits DNA gyrase & topoisomerase

7

Alpha Amanitin

Poison
Inhibits RNA poly I and II