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Flashcards in Growth Deck (9):
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stages of Age-Dependent Pattern of growth

Prenatal
Infancy
Juvenile growth - 85%height
Adolescent growth (pubertal) - final adult stature attained

1

Growth Hormones

growth hormone and somatomedin
Thyroid hormone
testosterone and estrogen
INsulin
PTH
Cortisol

2

T3 and growth

T3 is absolutely essential for normal growth of CNS during perinatal period (228 week gestation to 1 week after birth)

3

Growth Hormone & growth

Though necessary for total picture not super important for fetus growth.
IGF-1 (somatomedin) stimulates cell division in cartilage of the epiphyses, with its release stimulated by GH

4

Thyroid hormone (T3&T4) - role

not connected to fetal growth
Important for perinatal growth of CNS (lack of T3/T4 =mental retardation)
Effect on bone growth through permissive interactions with growth hormone and GH receptors
*Failure to grow in hypothyroid individual is the result of GH deficiency*
Contributes to bone ossification

5

Insulin & growth

Required for optimal growth
Regulates metabolism by promoting uptake of AA from blood (needed for muscle growth)
Stimulates Osteoblasts

6

Gonad Hormones & Growth

Growth spurt triggered by pubertal increase on concentrations
Promote lengthening of bones and closure of epiphyseal plates
Growth of skeleton during puberty PRIMARILY Estrogen in XX & XY
Estrogen often problem for female bone development at menopause

7

Glucocorticoids and Growth

Required for normal growth
Abnormally high concentrations of cortisol inhibit DNA synth and can inhibit normal growth
Cortisol - inhibit osteoblasts and osteoclasts
Exogenous admin of corticosteroids can lead to bone demineralization

8

FTT

Failure to Thrive (pediatric)
Below average growth. Organic (biological) or non-organic (environmental) causes