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Flashcards in Terminal Oxidation Deck (16):
0

Terminal Oxidation - def., parts, location

Produce ATP from reducing power of NADH and FADH
Electron transport and oxidative phosphorylation
Mitochondrial inner membrane

1

Sources of CoEnzymes + locations

Glycolysis (then transported to mitochondrial matrix)
PDH - cytosol
TCA - cytosol
Beta oxidation - cytosol

2

electron transport

Electron carriers transfer electrons and protons from reduced co-enzymes to oxygen

3

oxidative phosphorylation

reducing power of electron transport is converted into ATP energy

4

Components of electron transport chain

4 complexes
CoEnzyme Q
Cytochrome c

6

What happens to protons in ETC?

protons removed are pumped across membrane to create electrochemical gradient that provides energy for ATP synthesis

7

Complex I

NADH enters system, and transfers electrons and protons to CoQ (through FMN)

8

Complex II , driving enzyme

FADH enters system, transfers electrons and protons, to CoEnzyme Q (prefaced by succinate/fumarate)
-succinate dehydrogenase

9

CoEnzyme Q

Accepts electrons. Transfer them to Complex III

10

Complex III

transfers electrons to cytochrome c

11

cytochrome c

trasnports electrons to Complex IV

12

Complex IV

transfers electrons to molecular oxygen

13

What stops/damages ETC?

Carbon Monoxide, Sodium Azide, Potassium cyanide
Poison complex 4-b/c it works with molecular oxygen, (and hemoglobin)

14

What stops Complex III?

Antimycin - an antibiotic
also Myxothiazol and Stigmatelin

15

Cyanide Poisining - antidotes (+Fxn)

Nitrites - convert hemoglobin to methemoglobin by oxidizing Fe2+ to Fe3+
Methemoglobin then competes with cytochrome a3 (fe3+) for cyanide
causes small problem in blood cell oxygenation but overall allows for ETC to continue

16

What stops Complex I?

Rotenone (fish poison), Amytal (barbituate)