Breast Cancer TBL Flashcards Preview

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Flashcards in Breast Cancer TBL Deck (22):
0

Growth Factors

Naturally occurring substances that are capable of stimulating cell growth, proliferation and differentiation.

1

Epidermal growth factors

umm...

2

EGFR

mitogenic response ...?

3

Mitogen

chemical that triggers mitosis by activating signal transduction pathways in which mitogen-activated protein kinase (MAP kinase) is involved

4

Proto-oncogene

gene that regulates cell growth

5

oncogene

when a gene results in transformation of cells and uncontrolled cell growth

6

Mestasis

Spreading of cancer cells

7

Stage 0 BC

Carcinoma in situ

8

DCIS

Ductal Carcinoma in situ - abnormal cells in lining of the duct

10

Stage I

Cancer cells have not spread beyond the breast

11

Stage II

2-5cm wide
Spread to lymph nodes under arm

12

Stage III

locally advanced cancer
Tumor spread to underarm lymph nodes and to lymph nodes behind the breastbone

13

Stage IV

distant metastatic cancer
cancer spread to other parts of the body

14

Recurrent Cancer

Cancer that has come back after a period of time when it could not be detected. can reoccur locally or systematically.

15

Estrogen-receptors positive, %
Progesterone-receptor positive,%

75% ER positive
65% of ER positive = PR positive

16

Treatment for ER+ / PR+

Tamoxifin
Aromatase Inhibitors

17

Tamoxifin - def., function

Antagonist of the estrogen receptor
Blocks the binding of estrogen to ER

18

Aromatase Inhibitors - Function, Specifications

Block estrogen production
Used in postmenopausal women

19

Adjuvant therapy

Additional treament

20

Neoadjuvant therapy

therapy given before main treatment

21

Anthracycline - functions

Inhibits DNA and RNA synthesis by intercalating between base pairs, preventing cell replication
Inhibits topoisomerase II enzyme, preventing DNA supercoiled relaxation, blocking DNA transcription and replication
Creates free radicals that damage DNA and cell membranes of tumors

22

Taxol

Anti-microtubule agent
Acts on cell during cell division
Inhibits microtubule formation - hindering cell division and replication - resulting in cell death