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Flashcards in Oncogenesis Deck (12):
0

Causes of Cancers Paradigm (6)

1. Sustaining proliferative signaling
2. Evading growth suppressors
3. Activating invasion and metastasis
4. Enabling replicative immortality
5. Inducing angiogenesis
6. Resisting cell death

1

Immune system - cancer role

Surveillance, prevention, and elimination of cancer and pre-cancerous cells

2

Most common cancers assocaited with immunodeficiency

leukemias and lymphomas

3

Someone with damage to bone marrow is likely predisposed to...

leukemia

4

Effect of chromosomal instability and/or fragility

Increased chromosomal mutations and DNA damage
Cancer

5

p53.

Activated when DNA damaged detected
Arrests cell cycle at G1 to allow time for complex DNA repair machinery to fix damaged DNA or direct the cell through apoptosis
Failure leads to "immortal" cell and cancer

6

Transcription factors

Potent for active genes
Can inappropriately activate oncogenes that can lead to cancer

7

Tyrosine Kinase & cancer, what? i.e.

Uninhibited activity o tyrosine kinases can lead to cancer
Philadelphia chromosome and bcr/abl fusion protein is CML in the classic example of tyrosine kinase activity.

8

Growth factors & cancer

Uninhibited activity of growth factors can lead to caner. including loss of imprinting and heterozygousity

9

Tumor suppresor genes & cancer

Loss of tumor suppressors leads to over expression o oncogenes. Germline oncogenes often produce complex syndromes demonstration that oncogene expression is important in normal development

10

microanatomy & cancer

Restructuring microanatomy can lead to cell survival advantage therefore cancer

11

embryology & cancer

Embryology is regulated growth. Cancer is dysregulated growth in a delicate balance.
embryonic defects and large chromosomal changes are frequently associated with a cancer