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Flashcards in Cancer Hallmarks Deck (16):
0

Current Hallmarks of Cancer

Resisting cell death
Evading Growth Suppresors
Enabling replicative immortality
Sustaining cell signaling proliferation
Inducing angiogenesis
Activating invasion and metastasis

1

Emerging Hallmarks of Cancer

Deregulating cellular energetics
Avoiding immune destruction

2

Enabling Characteristics

Genome instability and mutation
Tumor-promoting inflammation

3

Error Possibilties

Somatic Mutations
Point Mutations
Deletion Mutations
Driver Mutations
Passenger Mutations

4

Somatic Mutations - types

Point Mutations
Translocations
Amplifications
Overexpressions

5

Point Mutations - types

Silent
Nonsense
Missense - conservative
Missense - non-conservative

6

Anti-Angiogenesis

Mostly effective in Kidney
No predictive biomarker

7

Chemotherapy - how

NA

Targets DNA or microtubles
????

8

Alkylating agents - effect, method

Forms bonds with amino carboxyl and phosphate groups.
Modify DNA
KILL CELL

9

Anti Metabolites - effect, method

Masquerade as purines and pyrimidines
Inhibit DNA synthesis
KILL CELL

10

Cytotoxic Antibodies - effect, method

Cause DNA strand breaks
Intercalate DNA
INhibit DNA and RNA synthesis
KILL CELL

11

Topoisomerase Inhibitors - effect, method

Inhibit DNA supercoiling
Result in inhibition of DNA and RNA function and synthesis
KILL CELL

12

Microtubule Targeting Agents - name

Vinca Alkaloids
Taxanes
Epothilones

13

Vince Alkaloids - effect, method

Inhibit assembly of tublin into microtubules
Prolonged mitotic delay
KILL CELL

14

Taxanes - effect, method

Enhance micro-tubules stability
Prolonged Mitotic delay
KILL CELL

15

Epotilones - effect, method

Enhance micro-tubules stability
Prolonged Mitotic delay
KILL CELL