General Connective Tissue x Flashcards Preview

Undeleted > General Connective Tissue x > Flashcards

Flashcards in General Connective Tissue x Deck (57):
1

CT Characteristics

Separated - Surrounded by ECM
Resident Cells & Wandering Cells
Well-Vascularized
Support Tissue
Derived from Mesoderm

2

Resident Cells

Fibroblasts
Adipocytes

3

Wandering Cells

Macrophages
Mast Cells
Lymphoctyes
Neutrophills wbc
Eosiniphills wbc
Basophils wbc

4

CT Fxns

Support frameworks and filler
Transport of nutrients
Storage of metabolites
Defensive responses
Tissue repair

5

Fibroblast - fxn, structure, other names

synthesis of CT fibers and ECM
Large, oval, pale nucleus
Chondroblast, Osteoblasts, Fibrocyte (inactive or quiescent)

6

Adipose Cells - types, characteristics/fxns

Unilocular, Multilocular
Sensitive to neural and hormonal control
Thermal Insulation
Produces Leptin
Shock absorbers
Space filler
50-150un
Surrounded by basal lamina - highly vasularized
15-25% body weight

7

Unilocular - name, fxn, structure

White - Adults, Storage of neutral fats (triglycerides), 1 lrg lipid droplet

8

Multilocular - name, fxn, structure

Brown - Newborns, Production of heat, numerous small lipid droplets

9

Hyperplastic, Hyperthrophic

increase in the overall number of cells.
Increase in the size of individual cells.

10

Leptin

Hormone that Inhibits appetite and stimulates metabolic rate

11

Macrophages - Characteristics/fxn

Part of mononulcear phagoctye system
Immune response - antigen presentation
Ingests particles w/ lysosomes
Derived from blood monocytes
Nucleus - oval or kidney shape

12

Specialized names for Macrophages + location

Histocytes
Dust cells/Alveolar Macrophages - lungs
Kupffer Cells - liver
Microglia - neural tissue
Osteoclasts - bone

13

Mast Cells - presentation, characteristics

Large, oval or elongate cells
bright purple (or pink) staining granules (basophillic)
Originate in bone marrow
Meditate inflammatory process, acute inflammation
Mediate immediate hypersensitivity reactions

14

Degranulation

Many IgE receptors on mast cell so binds IgE
IgE binds Ag -->-->--> Ca2+ release --> Mast granule fusion with plasma membrane and content release initiating inflammatory response.

15

Mast Cells release

Preformed mediators and newly systhesized mediatiors

16

Preformed mediatiors - def, types

released by mast cell granules
Histamine
Serine proteases
Heparin
Eosinophil chemotatic factor

17

Histamine - fxn

Increased capillary permeability = edema
Blood vessel dilation
in airways - increase mucus and smooth muscle contraction

18

Serine proteases - types, fxns

tryptase, chymase (role in angiotensis II production)

19

Heparin

sulfated GAG , anticoagulant

20

Newly synthesized mediators - def, types

Lipids and Cytokines made and released after mast cell activation and degranulation
-Leukotrines
-TNFalpha
-INterleukins

21

ECM components

ground substance
fibers

22

Ground substance - def/types

amorphous and viscous intracellular mixture of proteglycans, structural glycoproteins and tissue fluid

23

GAG - a.k.a, def

Glycosaminoglycans
long unbranched disaccarides with strong negative charge, attracts cations, attracts water, resist compression

24

Proteoglycans - def, fxn

GAG + protein core
attached via link protein to hyaluronic acid
Gel state in ECM - compression resistance
Barrier functions

25

Structural Glycoproteins - def, types/location

binds cell to ECM - cell adhesion, migration, signaling
fibronectin - fibroblasts
laminin - epithelial cells
chonrocytes - chondrocytes
osteonectin - bone

26

Fibronectin

from fibroblasts found in ECM
has binding sites for multiple components

27

Laminin

from epitihelial cells
found in basal lamina
binds to collage (type IV), intergrins, heparin, entactin
ability to cross link very well

28

Tissue fluid - from, fxn

derived from blood plasma
bound to neg. charge GAG
transports nutrients and wasted nu hydro-static and osmotic pressure.

29

Edema

abnormal increase in CT fluid
associated w inflammation, venous obstruction or starvation (fall in colloid osmotic pressure)

30

FIbers

Collagen
Reticular Fibers
Elastic Fibers

31

Collagen - staining, # types

Bifringent
Inelastic
stains pink w/ H&E
stains blue w/ Mallorys trichrome
4 major types

32

Collage Type I - location, function

tendon, dermis, bone, ligaments, cornea, dentin
Tensile strength

33

Collagen Type II - location, function

cartilage, nucleus pulposus, vitreous body
Resistance to Compression

34

Collagen Type III - location, function

smooth muscle, vessels, fetal skin
Compliance - ability to change shape a little

35

Collagen Type IV - location, function

Basal Laminae
Support and filtration Barrier

36

Collage Type I - Cell types, Structure

Fibroblast
Fibers - large

37

Collage Type II - Cell types, Structure

Chondrocyte
Fibrils - small

38

Collage Type III - Cell types, Structure

Fibroblasts, 'reticular', smooth mucscle, schwann, hepatpcytes

39

Collage Type IV - Cell type, Structure

Epithelia, endothelium, Schwann, Muscle fibers

40

Fiber - layers

Molecules x Many = Fibrils x many = FIibers x many = Bundle

41

Reticular Fibers - characteristics, fxn

seen in type III collagen
Argyrophillic (silver staining)
only form fibrils and fibers
Provide support and change in shape

42

Elastic FIbers

provide stretch and recoil
Yellow appearance,
need special stains
Found in aorta

43

ECM interface - fxns, types

adhesion, communication and cell movements
Transmembrane structural glycoproteins
Basement Membrane

44

Transmembrane structural glycoproteins, - type, fxn

Intergrins and dystoglycans
Adhesion, traction and bidirectional signaling

45

Basement Membrane - layers

Lamina lucida, Lamina densa, Lamina reticularis
Can see with light microsope

46

Connective tissue classifiaction

Loose/ Areolar CT
Dense CT

47

Loose/ Areolar CT - def, arrangement, fxns

Grounds substance predominates
Loose arrangement
-Support epithelium
-Lines body cavities
-Ensheates blood vessels

48

Dense CT - def, fxn, types

fibers predominate
resist stress
Regular (tendon) and Irregular (dermis sclera)

49

Lamina Propria

Loose CT in mucosa

50

Regular Dense CT - arrangement

fibrillar components arranged in same direction

51

Irregular Dense CT - arrangement

FIbers are in mesh=like arrangement
Can be moved/ strong in more than one plane

52

Reticular CT - arrangement

mesh-like

53

Adipose CT

more cells than matrix (unlike other CT)

54

Elastic CT - arrangement

Sheets/Lamallae

55

Embryonic CT - def, types

Undifferentiatied CT
Mesenchymal
Mucoid

56

Messenchymal - characteristics

only in embyro
scattered fibers - spindle or start shaped

57

Mucoid - characteristics

Found only in umbilical coil
Loose amorphous
Hylauronic acid - gel state of ECM