Antifungal Flashcards Preview

Topnotch Pharmacology (Sept 2017) > Antifungal > Flashcards

Flashcards in Antifungal Deck (21):
1

Sporothrix schenckii

Itraconazole or POTassium iodide(plant a rose in a pot)

2

Coccidiodes immitis

Amphotericn b/ itraconazole; fluco for meninitis

3

Histoplasma capsulatum

Amphotericin/ itraconazole; fluco for meningitis

4

Blastomyces dermatitidis

Itraconazole

5

Paracoccidioidea brasilensis

Itraconazole

6

Candida

Oropharyngeal and esophageal- nystagin swish and swallow; skin- clotrimazole; disseminated candidiasis- amphotericin B; chemoprophylaxis- fluconazolr

7

Cryptococcus neoformans

Ampho/ flucytosine; chemoproph: fluconazole

8

Aspergillus fumigatus

Amphotericin B

9

P jiroveci

TMP- SMX

10

Malassezia furfur

Miconazole

11

Polyene antifungal that binds to ergosterol forming artificial pores

Amphotericin B
Nystatin

12

Amphotericin B: Fungicidal or Fungistatic?

Fungicidal

13

Accumulates in fungal cells by the action of permease and converted to cytosine deaminase to 5-FU.

Flucytosine

14

A pyrimidine antimetabolite antifungal

Flucytosine

15

Inhibit fungal P450-dependent enzymes blocking ergosterol sysntesis

Azoles (Keto, Fluco, Itraco)

16

Antifungal with good CNS permeability

Fluconazole

17

Inhibits B-glucan synthase decreasing fungal cell wall synthesis

Caspofungin

18

Antifungal that accumulates in keratin. Contraindicated in porphyria

Griseofulvin and Terbinafine

19

Interferes with microtubule function. Inhibits sysnthesis and polymerization of nucleic acids,

Griseofulvin

20

Interfere with ergosterol synthesis by inhibiting fungal squalene oxidase.

Terbinafine

21

DOC for pityriasis versicolor

Clotrimazole