Bacterial Protein Synthesis Inhibitors Flashcards Preview

Topnotch Pharmacology (Sept 2017) > Bacterial Protein Synthesis Inhibitors > Flashcards

Flashcards in Bacterial Protein Synthesis Inhibitors Deck (18):
1

as the plasma level is increased above the MIC, an increasing proportion of bacteria are killed and at a more rapid rate

Concentration-Dependent Killing Action

2

efficacy is directly related to time above MIC

Time-Dependent Killing Action

3

efficacy independent of concentration once the MIC has been reached

Time-Dependent Killing Action

4

killing action continues when their plasma levels have declined below measurable levels

Post Antibiotic Effect

5

narrowest therapeutic window among aminoglycosides

Amikacin

6

blocks the formation of the initiation complex

Aminoglycosides

7

infections caused by aerobic gram-negative bacteria (E. coli, Enterobacter, Klebsiella, Proteus, Providencia, Pseudomonas, Serratia) Endocarditis, Ocular infections

Gentamicin

8

most vestibulotoxic and nephrotoxic aminoglycosides

Gentamicin and Tobramycin

9

nephrotoxicity (reversible), ototoxicity (irreversible), neuromuscular blockade

Gentamicin

10

Multi-Drug Resistant Tuberculosis (2nd line drug)

Amikacin

11

least resistance among aminoglycosides but with narrowest therapeutic window

Amikacin

12

Tuberculosis, Tularemia, Bubonic plague, Brucellosis

Streptomycin

13

Teratogen (congenital deafness)

Streptomycin

14

skin infections, Bowel preparation, Hepatic encephalopathy

Neomycin

15

Leishmaniasis

Paromomycin

16

most ototoxic

Kanamycin

17

reverse neuromuscular blockade with Calcium gluconate and Neostigmine

Neomycin

18

Drug-resistant gonorrhea, Gonorrhea in penicillin-allergic patients

Spectinomycin