Antihypertensive Flashcards Preview

Topnotch Pharmacology (Sept 2017) > Antihypertensive > Flashcards

Flashcards in Antihypertensive Deck (17):
1

inhibit na/cl transporter in distal convoluted tubules. reduce excretion of calcium. for hypertension ( first line).

hydrochlorothiazide

2

loop diuretic. inhibit na/k/2cl in thick ascending loop of henle. powerful diuresis and increase ca excretion. for heart failure, PULMONARY EDEMA.

furosemide

3

activates a2 which decreases central symphatetic outflow. for hypertension. side effect: Rebound hypertension,

clonidine

4

activates a2 adrenergic receptor. for Pre Eclampsia. Se: sedation, Hemolytic Anemia

methyldopa

5

ganglion blocker, competitively blocks nicotinic ach receptors. for Hypertension (obsolete). SE: Postural Hypertension, dry mouth.

hexamethonium

6

nerve terminal blocker, irreversibly blocks the vesicular monoamine transporter(vmat) for Hypertension. (obsolete) SE: sedation, Suicidal Ideation.

reserpine

7

adrenergic antagonist A1 selective. for BPH, hp. SE: first dose orthostatic hypotension.

prazosin

8

blocks b1 and b2 receptors. for angina prophylaxis, Hypertension, arrhytmias, migraine. may mask hypoglycemia in diabetics.

propranolol

9

vasodilator, relaxes arteriolar smooth muscle, causing vasodilation, for hypertension, heart failure. SE: edema, reflex tachycardia, MI, Drug Inducrd Lupus

hydralazine

10

vasodilator, open k+ in vascular smooth muscle causing relaxation and vasodilation. for hypertension, Alopecia. SE: Hypertrichosis, pulmonary hpn, pericarditis.

minoxidil

11

block voltage gated L type calcium channel. for Supraventricular Tachycardia, migraine. SE: Gingival Hyperplasia, pretibial edema, av block

verapamil

12

block L type calcium channels. for Angina, Hypertension. SE: Pretibial edema, nausea, flushing, dizziness

nifedipine

13

vasodilator. for Hypertensive Emergency, acute heart failure, cardiogenic shock. SE: Cyanide toxicity

nitroprusside

14

dopamine agonist, causes vasodilation of afferent and efferent arterioles, for Hypertensive emergency. SE: hypotension, hypokalemia

fenoldam

15

ace inhibitor, for Hypertension, heart failure, post MI, diabetic nephropathy. * delays progression of DM nephropathy.

captopril

16

angiotensin receptor blocker, for hypertension, heart failure, diabetic nephropathy SE: hypotension, teratogen, hyperkalemia

losartan

17

renin antagonist. for hypertension, SE: headache, diarrhea,Angioedema, renal impairment.

aliskiren