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Topnotch Pharmacology (Sept 2017) > Autonomics > Flashcards

Flashcards in Autonomics Deck (71):
1

Blocks ACh synthesis(choline acetyltransferase)

Hemicholium

2

Blocks storge of ACh

Vesamicol

3

Alter synaptobrevins to prevent release of Ach

Botulinum

4

Indirect acting cholinomimetics

Neostigmine, carbamates, organophosphates

5

Direct acting cholinomimetics include:

Betanechol, pilocarpine, nicotine

6

For bowel and bladder atony

Bethanechol( BBB)

7

Glaucoma, sjogren syndrome, sicca syndrome

Pilocarpine

8

Activates M3 receptors in ciliary muscles and salivary glands

Pilocarpine

9

Xerostomia, xerophthalmia, rheumatoid arthritis

Sjogren syndrome

10

Activates nicotinic Ach receptors

Nicotine/ varenicline

11

Used for smoking cessation

Varenecline

12

Mushroom poisoning

Inocybe and amanita muscaria

13

Indirect acting cholinomimetics

edrophonium, neostigmine, rivastigmine

14

Diagnosis of MG(Tensilon Test), cholinergic crisis vs myasthenic crisis

Endrophonium

15

Managment of MG, oglilvie syndrome, glaucoma

Neostigmine

16

Muscarinic effects of neostigmine is blocked by this drug

Atropine

17

Indirect acting cholinomimetic used for alzheimer's

Rivastigmine

18

Signs and symptoms of organophosphate poisoning

DUMBBELS- diarrhea, urination, miosis, bronchospasm, bradycardia, excitation, lacrimation, sweating, salivation

19

Competitively blocks all muscarinic receptors

Atropine

20

Antidote for organophosphate poisoning, bradycardia, hypersalivation, mydriatic, cyclopegic

Atropine

21

Binds phophorus of organophosphate, breaks organophosphate bond with cholinesterase

Pralidoxime

22

Cholinoreceptor blockers

Atropine, benztropine,ipratropium, scopolamine

23

Competitevely blocks all muscarinic receptors , restores neurotransmittet balance in the basal ganglia

Benzotripine/ biperiden

24

Cholinergic antagonist used for parkinson's disease

Benztropine/ parkinson's disease

25

Muscarinic antagonists for parkinsonism

Try to park your benz, bip here ( muscarinic antagonist for parkinsonism)

26

Asthma, copd

Ipratropium

27

Competitively blocks all muscarinic receptors, antagonizes histamine and serotonin

Scoplamine

28

Used in motion sickness

Scopolamine

29

S/sx of atropine toxicity

Hot as a hare, dry as a bone, red as a beet, blind as a bat,mad as a hatter

30

Ganglion blocker used for hypertension

Hexamethonium

31

Only depolarizing neuromuscular blocker

Succinylcholine (kapag nakapag deposit ka, success yun)

32

Inhibits hydroxylation of tyrosine to dopa

Metyrosine

33

Inhibits vesicular transport of norepinephrine and dopamine

Reserpine

34

Increases stores of NE and dopamine

MAOI

35

Inhibits release of NE and dopa

Guanethidine

36

Promotes release of NE and dopa

Amphetamines and tyramine

37

Inhibits termination of NE and dopa

Cocoaine and TCAs

38

Activates a1,b1 and b2

Epi/NE

39

Sympathomimetics:

Epinephrine, norepinephrine, dopamine

40

Activates a1,b1, and d1

Dopamine

41

Dose of dopamine that causes vasodilation in the splanchnic and renal vascular beds

1-5 mcg/kg/min

42

Dose of dopamine that increases renal blood flow , heart rat, cardiac contractility and b1 receptors

5-15 mcg/kg/min

43

Vasoconstriction and increased blood pressure

>15 mcg/kg/min

44

Non selective activator of B adrenergic receptors used for asthma

Isoprotetenol

45

Selective alpha1 agonist

Phenlyephrine, pseudoephedrine

46

Selective alpha2 agonist

Clonidine, methyldopa, apraclonidine

47

Selective Beta1 agonist

Dobutamine

48

Selective B2 agonist

Albuterol/salbutamol

49

Used in preeclampsia

Methyldopa

50

A2 selective agent in glaucoma

Apraclonidine

51

Used in cardiac stress testing

Dobutamine

52

Drug of choice for acute asthma attack

Albuterol/salbutamol

53

Nonselective alpha blockers:

Phenoxybenzamine, phentolamine

54

Used for pheochromocytoma

Phenoxybenzamine

55

Irreversible blocks a adrenergic receptors

Phenoxybenzamine

56

Reversibly blocks a adrenergic receptors

Phentolamine

57

Management for a1 agonist overdose and rebound hypertension

Phentolamine

58

Selective a1 blockers

Prazosin, tamsulosin, terazosin

59

Selectively blocks a1 adrenergic receptors- used for benign prostatic hyperplasia

Prazosin,tamsulosin

60

Beta nonselective sympathomimetic

Isoproterenol

61

Nonselective beta blocker

Propanolol

62

Selective b blocker(b1)

Atenolol

63

Blocks b1 and b2 receptors, blocks sympathetic effects on heart and BP, reduces renin releaae

Propanolol

64

Used for performance anxiety

Propanolol

65

Drugs with intrinsic sympathomimetic activity

Acebutolol, pindolol

66

Nonselective beta blocker with the longest half life

Nadolol

67

Selective b1 blocker

Atenolol

68

Flow of aqueous humor

Ciliary body, posterior chamber, anterior chamber angle pupil anterior chamber, trabecular meshwork canal of shlemm uveoscleral veins

69

Increases outflow through canal of schlemm

Latanoprost

70

Increased outflow via uveosacral veins

Epinephrine

71

Ciliary muscle contraction, opening of trabecular meshwork, increased outflow

Pilocarpine, physostigmine