Lipid Drugs Flashcards Preview

Topnotch Pharmacology (Sept 2017) > Lipid Drugs > Flashcards

Flashcards in Lipid Drugs Deck (26):
1

Lipid lowering drugs

HMG CoA reductase inhibitor, resins, ezetimibe, niacin, fibrates

2

Drugs most effective at lowering triglyceride and VLDL and raising HDL

Niacine, fibrates

3

Reversible inhibitor of HMG CoA reductase

Statins (simvastatin etc)

4

Binds bile acids, preventing reabsorptionb of bile acids and increasing cholesterol utilization for replacement

Cholestyramine

5

Cholestyramine is CI in

Diverticulitis

6

Selective inhibitor of the NPC1L1 transporter

Ezetimibe

7

Most effective agent for raising HDL

Niacin

8

Drugs that cause flushing

VANC(vancomycin, adenosine, niacin, calcium channel blockers)

9

DOC for hypertriglyceridemia

Gemfibrozil

10

Increased risk of myopathy and rhabdomyolysis

Statins & gemfibrozil

11

Drugs most effective at lowering LDL

Statins, resins, ezetimibe, niacin

12

Clear VLDL and LDL remnants from blood

High affinity LDL receptors

13

Statins have an increased risk of rhabdomyolosis and myopathies when given with wc drug

Fibrates

14

Anithyperlipidemic combination that may cause increased risk for cholelithiasis

Fibrate+ resin

15

Anithyperlipidemic combination that may cause impaired statin absorption

Statin+ resin

16

Inherited lipoprototeinemia with deficiency in LPL or ApoC II

Type 1 primary hyperchylomicronemia/ familial lipoprotein lipase deficiency

17

Inherited lipoprototeinemia with deficiency/defect in LDL receptors

Familial hypercholesterolemia -II

18

Inherited lipoprototeinemia with deficiency in ApoE

III- Familial dysbetalipoprotenemia

19

Inherited lipoprototeinemia with decreased clearance or increased production of VLDL

IV- Familial hyperyriglyceridemia

20

Xanthomas, pancreatitis, no increased risk of coronary heart disease

I- Primary hyperchylomicronemia

21

Xanthomas, xanthelasmas with increased risk of atherosclerosis

II- Familial hypercholesterolemia

22

Triad of cornary artery disease, DM type 2, obesity

Familial hypertriglycerdiemia

23

Cholesterol analog, takes the place of dietary and biliary cholesterol, decreasing intestinal absorption of cholesterol and other phytosterols

Sitosterol

24

Lipid lowering drug that also has an indication for digitalis toxicity

Cholestyramine

25

Lipid lowering drug that may cause flushing

Niacin

26

If given pretreatment may reduce flushing

Aspirin