Drugs Used In Parkinsonism Flashcards Preview

Topnotch Pharmacology (Sept 2017) > Drugs Used In Parkinsonism > Flashcards

Flashcards in Drugs Used In Parkinsonism Deck (28):
1

Parkinsonism is due to

Degeneration of dopaminergic neurons in substantia nigra

2

Drug induced parkinsonism is due to

Typical antipsychotics, reserpine, MPTP(methylphenyltetrahydropyridine)

3

Alternating periods of improved mobility and akinesia

On-Off phenomena

4

deterioration of drug effect in betweem medication dosese

Wearing off phenomena

5

Wearing off effect due to

destrucion of nigrostriatial neurons

6

Primary drug for Parkison's

Levodopa Carbidopa

7

Carbidopa inhibits peripheral metabolism via

Dopa carboxylase

8

Levodopa Carbidopa CI in

Psychosis

9

Bromocriptine is partial agonist of

D2 receptors in brain

10

Used for levodopa intolerance and hyperprolactinemia

Bromocriptine

11

May cause erythromelalgia

Bromocriptine

12

Partial agonist at D3 receptors

Pramipexole

13

SE: Compulsive gambling, overeating

Pramipexole

14

Also for restless leg syndrome

Pramipexole

15

Partial agonist at D3 receptors. Antagonizes 5HT and alpha adrenoreceptors

Apomorphine

16

Used for Off Periods

Apomorphine

17

Also for alcoholism, Opiate addiction, Erectile dysfunction and Alzheimer's

Apomorphine

18

When giving Apomorphine what premedication is given

Trimethobenzamide

19

MAO type B inhibitor, leades to decreased degredation of dopamine; Increases response to dopamine

Selegiline

20

Serotonin syndrome when used with SSRI

Selegiline

21

COMT inhibitor, thus blocks L dopa metabolism

Entacapone

22

For Wearing Off phenomena

Entacapone

23

Potentiates dopaminergic action, Influences synhtesis release or reuptake of dopamine at Adenosine 2A receptors

Amantadine

24

Blue red lacy pattern at extremities

Livedo reticularis

25

Decrease excitatatory actions of cholinergic neurons on cells in the striatum by blocking muscarinic receptors

Benztropine

26

For extrapyramidal sx caused by antipsychotics

Benztropine

27

Drugs used in Parkinsonism

Bromocriptine, Pramipexole, Apomorphine, Selegiline, Entacapone, Amantadine, Benztropine

28

Parkinsonism is also known as

Paralysis agtans