Antivirals Flashcards Preview

Topnotch Pharmacology (Sept 2017) > Antivirals > Flashcards

Flashcards in Antivirals Deck (19):
1

Drugs used for herpes

Acyclovir, ganciclovir, foscarnet

2

Drugs for influenza

Amantadine, zanamivir

3

Drugs for HBV and HCV

Inf-a, lamivudine, ribavirin

4

Activated by thymidine kinase to formals that inhiit viral DNA polymerase

Acycolvir

5

Inhibits viral DNA polymerase , causing chain termination

Ganciclovor

6

Inhibits RNA polymerase, DNA polymerase and HIV reverse transcriptase. Binds to pyrophosphate binding site.

Foscarnet

7

DOC for CMV retinits(?)

Cifodovir

8

Antiviral that can cause hypocalcemia

Foscarnet

9

Drugs for HIV

Indinavir, enduvirtide, maraviroc, zidovudine, delavirdine (nucleoside reverse transcriptase inhibitor, nnrti, protease inhibitor, fusion inhibitor, ccr5 receptor antagonist)

10

Inhibits HIV transcriptase after phosphorylation by cellular enzymes

Zidovudine

11

Inhibit reverse transcriptase. No phosphorylation required.

Delavirdine

12

Inhibits viral protein processing

Indinavir

13

Binds to gp41 subunit of viral envelope glycoprotein, preventing fusion of viral and cellular membranes

Enfuvirtide

14

Blocks viral attachment via transmembrane chemokine receptor CCR5

Maraviroc

15

Inhibit early step replication and prevent UNCOATING by binding yo M2 proton channels

Amantadine

16

Inhibits neuraminidase. Decreases release of progeny virus.

Oseltamivir

17

Degrades viral RNA via activation of host cell RNAase(ribonuclease)

Interferon a

18

Inhibits HBV DNA polymerase

Lamivudine

19

Inhibits guanosine triphosphate formation. Prevents capping of viral mRNA. Blocks RNA dependent RNA polymerase

Ribavirin