Antiparasitics 1

Question 0

Amoebiasis

Answer 0

Diloxonide
Paramomycin
Metronidazole

Question 1

Giardia

Answer 1

Metronidazole

Question 2

Metronidazole moa

Answer 2

N group accepts e- from ferrodoxin of amoebic parasite
Reductive bioactivation produces cytotoxic products
React with protein and DNA

Question 3

For severe amoebiasis, hepatic amoebic abscess, extraintestinal amoebiasis

Answer 3

Metronidazole

Question 4

Can metronidazole penetrate the bbb?

Answer 4

Yes! Can be used to treat B fragilis brain abscess

Question 5

First line drug for C difficle colitis

Answer 5

Metronidazole

Question 6

Only aerobic bacteria that metronidazole can affect

Answer 6

Helicobacter pylori

Question 7

Dry mouth with metallic taste, pancreatitis, ataxia, encephalopathy, seizures, dizziness, vertigo, disulfiram like reaction

Answer 7

Metronidazole

Question 8

Metronidazole kind of drug

Answer 8

Nitromidazole

Question 9

Diloxinide furoate can affect which stage of amoeba?

Answer 9

Before encystment

Question 10

Entamoeba histolytica cyst, not active against trophozoites

Answer 10

Diloxonide

Question 11

Malaria caused by 4 species of Plasmodium

Answer 11

Falciparum
Vivax
Ovale
Malariae

Question 12

Most common plasmodium in the phil

Answer 12

Falciparum

Question 13

2nd most common plasmodium in the phil

Answer 13

Vivax

Question 14

Current P falciparum resistance profile in the phil

Answer 14

Artemether
Chloroquine
Fansidar

Question 15

Most number of cases of malaria in the Philippines

Answer 15

Palawan

Question 16

3 stages of Plasmodium cycle

Answer 16

Exo-erythrocytic
Erythrocytic
Sporogonic

Question 17

Gut of mosquito

Answer 17

Sporogonic

Question 18

Liver of human

Answer 18

Exo-erythrocytic

Question 19

First line malaria treatment Philippines

Answer 19

Coartem

Question 20

Only tissue schizontocide

Answer 20

Primaquine

Question 21

Treatment regimen for uncomplicated vivax malaria

Answer 21

Day 0 and 1 CQ 150 mg, 10mg/kg/day, 4 tab/day

Day 2 CQ 150mg, 5mg/kg/day, 2 tab

Day 3 to 17 Primaquine, 15mg, 0.5mg/kg/d, 1 tab

Question 22

Primaquine contraindicated in

Answer 22

Severe g6pd

Question 23

Malaria prophylaxis drugs

Answer 23

Mefloquine

Doxycycline

Question 24

Antibacterial 2nd line drugs for malaria

Answer 24

Tetracycline Doxycycline Clindamycin

Question 25

Coartem

Answer 25

Artemether-lumefantrime

Question 26

Very rapidly acting blood schizonticide against all malaria parasites, no effect on liver stage

Answer 26

Artemether

Question 27

Artemether contraindicated for pregnant women?

Answer 27

NO!

Question 28

Artemether metabolite

Answer 28

Dihydroartemisinin

Question 29

Artemesia in the Philippines

Answer 29

Vulgaris

Question 30

Endoperoxide containing natural antimalarials from sweet wormwood

Answer 30

Artemisinin

Question 31

Lumefantrine, when taken with food

Answer 31

Improved absorption

Question 32

Minor arrhythmia and long qt

Answer 32

Coartem

Question 33

Quinine effect adverse

Answer 33

Cinchonism | Git distress, headache, vertigo, blurred vision, tinnitus

Question 34

Quinine moa

Answer 34

Complexes with dsDNA preventing separation

Question 35

Therapeutic dose may cause hypoglycemia by insulin release, especially in severe infections in pregnant patients

Answer 35

Quinine

Question 36

Not usually used unless sure that it is vivax

Answer 36

Chloroquine

Question 37

Prevents biocrystallization of parasite heme into hemozoin causing heme buildup and parasite lysis

Answer 37

Chloroquine

Question 38

Alopecia, hair bleaching, hypotension, widened qrs, abnormal t waves

Answer 38

Chloroquine

Question 39

Antifolate drugs, malaria

Answer 39

Pyrimethamine | Sulfadoxime

Question 40

Fansidar

Answer 40

Fixed combination Sulfadoxime and Pyrimethamine

Question 41

May cause folic acid deficiency

Answer 41

Pyrimethamine

Question 42

Eradicates exoerythrocytic and gametocytic forms

Answer 42

Primaquine

Question 43

With longer tissue stage, falciparum or vivax?

Answer 43

Vivax

Question 44

How many days of primaquine?

Answer 44

Falciparum 1 | Vivax 14