Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharm > Autonomics IV > Flashcards

Autonomics IV Flashcards

1
Q

What is the role of angiotensin?

A

Vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the role of aldosterone?

A

Decreases excretion of Na

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What drive the increase in blood pressure from the kidneys: sympathetic or parasympathetic drive?

A

Sympathetic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

True or false: if you use enough of a drug, selectivity will be lost

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the three classifications of adrenergic receptor agonists?

A

direct acting
Mixed acting
Indirect acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the MOA of direct acting adrenergic agonists?

A

Directly agonize the receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the three ways in which indirect acting adrenergic agonists increase the availability of NE, and epi?

A
  1. Release NE from nerves
  2. Block transport of NE into symp neurons
  3. Block metabolizing enzymes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the MOA of mixed adrenergic agonists?

A

Indirectly release NE and also directly activate receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What receptor does phenylephrine agonize?

A

Alpha 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What receptor does clonidine act on?

A

Alpha 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What receptors does terbutaline act on?

A

Beta 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What receptor does fenoldopam work on?

A

D1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What receptors does isoproterenol work on?

A

Beta 1, 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the receptors that dobutamine acts on?

A

beta 1, beta 2, alpha 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the receptors that epinephrine acts on?

A

alpha 1, alpha 2, beta 1, beta 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the receptors that NE acts on?

A

alpha 1, alpha 2, beta 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are the receptors that dopamine acts on?

A

D1, D2, alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are the receptors that ephedrine acts on?

A

alpha 1, alpha 2, beta 1, beta 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Why aren’t selective or nonselective adrenergic agonists affected by reserpine or guanethidine?

A

Directly antagonize

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the only mixed acting adrenergic drug discussed in class?

A

Ephedrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Direct acting or indirect acting: phenylephine. If direct acting, is it selective or non selective?

A

Direct

Selective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Direct acting or indirect acting: ampmhetamine. If direct acting, is it selective or non selective?

A

indirect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Direct acting or indirect acting: clonidine. If direct acting, is it selective or non selective?

A

Direct

selective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Direct acting or indirect acting: terbutaline. If direct acting, is it selective or non selective?

A

direct

selective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Direct acting or indirect acting: fenolopam. If direct acting, is it selective or non selective?
Direct | Selective
26
Direct acting or indirect acting: cocaine. If direct acting, is it selective or non selective?
Indirect
27
Direct acting or indirect acting: tyramine. If direct acting, is it selective or non selective?
Indirect
28
Direct acting or indirect acting: isoproterenol. If direct acting, is it selective or non selective?
direct | Non-selective
29
Direct acting or indirect acting: epinepherine. If direct acting, is it selective or non selective?
Direct | Non-selective
30
Direct acting or indirect acting: NE. If direct acting, is it selective or non selective?
Direct | Non-selective
31
Direct acting or indirect acting: dopamine. If direct acting, is it selective or non selective?
Indirect | Non-selective
32
True or false: mixed acting drugs are affected by prior treatment with reserpine
True
33
True or false: indirect acting adrenergic drugs' effects are completely abolished by prior treatment with reserpine
True
34
Direct acting or indirect acting: paragyline. If direct acting, is it selective or non selective?
Indirect
35
Direct acting or indirect acting: entacapone. If direct acting, is it selective or non selective?
indirect
36
Wha is the MOA of amphetamine?
Cause release of adrenergic neurotransmitters
37
Wha is the MOA of tyramine?
Cause release of adrenergic neurotransmitters
38
Wha is the MOA of cocaine?
Inhibits the reuptake protein (NET1)
39
What type of drug is pargyline?
indirect acting adrenergic MAOI
40
What type of drug is entacapone?
indirect acting adrenergic MAOI
41
What receptor does phenylephrine (neo-synephrine) work on? What does this cause/what is it used for?
alpha 1 | Increased BP, TPR (treats hypotension)
42
Why is phenylephinre used to treat paroxysmal atrial tachycardia?
Increased BP causes reflex bradycardia
43
if using phenylephrine to cause mydriasis, will the eye still be able to accomodate? Why?
Yes, because M3 receptor still intact
44
What is the receptor that alpha-methyldopa acts on?
alpha 2
45
What is the receptor that apraclonidine acts on?
alpha 2
46
What is the receptor that brimonidine acts on?
alpha 2
47
What are the alpha 2 agonists like clonidine used for?
Lowers BP | Decrease aqueous humor production
48
What is the receptor that metaproterenol acts on?
beta 2
49
What is the clincial use of beta 2 receptor agonists like metaproterenol (metaprel) and terbutaline (bricanyl)?
Long term treatment of obstructive airway disease
50
Why isn't metaproterenol used to treat asthma?
Not as good as albuterol beta 2 selection
51
Which is a substrate for the enzyme COMT: metproterenol (metaprel) or terbutaline (bricanyl)?
metaproterenol
52
What is the receptor that albuterol (ventolin, salbutamol) acts on?
beta 2
53
What is the receptor that ritodrine (yutopar) acts on? What is its therapeutic use?
beta 2 | Uterine relaxant
54
What are the adverse effects of beta 2 activation?
tachycardia
55
What drugs should never be used in combination with beta 2 agonists?
MAOIs
56
Why is there a decrease in serum K with the use of beta 2 agonists?
activate the uptake of K from blood into muscle
57
True or false: all of the adverse effects of beta 2 agonists are less if administered via inhalation
True
58
What is the receptor that fenoldopam (corlopam) acts on?
D1
59
What is the cinical use of fenoldopam (corlopam)?
HTN crises
60
What are the receptor that isoproterenol (isuprel) acts on?
Beta 1, beta 2
61
What is the clinical use of isorpterenol (isuprel)?
Decrease TPR, Increase HR (treat bradycardia)
62
What are the receptors that dobutamie (dobutrex) stimulates?
Beta 1, alpha 1, beta 2 But mainly beta 1
63
What is dobutamine used for?
Increases contraction of heart, without much increase in HR
64
What are the adverse effects of dobutamine (dobutrex)?
Excessive increases in BP/HR
65
How can dobutamine (dobutrex) worsen an MI?
Increase size d/t increase tissue demand for oxygen

Pharm (73 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions