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Master Drug List Flashcards

1
Q

Acetylcholine

A

Direct acting muscarinic agonist

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2
Q

Methacholine

A

Direct acting muscarinic agonist

Used to test for asthma

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3
Q

Carbachol

A

Direct acting muscarinic agonist

Used in treatment of glaucoma

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4
Q

Bethanachol

A

Direct acting muscarinic agonist

Used to treat urinary retention (M3 receptor specific)

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5
Q

Muscarine

A

Direct acting nicotinic agonist

Found in mushrooms–atropine is the antidote

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6
Q

Pilocarpine

A

Direct acting nicotinic agonist

Used to treat glaucoma by contacting ciliary muscle (M3 specific)

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7
Q

Nicotine

A

Direct acting nicotinic agonist

Activates both Nm and Nn receptors

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8
Q

Edrophonium

A

Reversible, indirect acting cholinoceptor agonist

Used to diagnose myasthenia gravis

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9
Q

Neostigamine

A 
Reversible, indirect acting cholinoceptor agonist
Treat ileus (stimulates M3), myasthenia gravis
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10
Q

Pyridostigamine

A 
Reversible, indirect acting cholinoceptor agonist
Treat ileus (stimulates M3), myasthenia gravis
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11
Q

Donepezil

A

Reversible, indirect acting cholinoceptor agonist

Alzheimer’s balance of dopamine/ACh

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12
Q

Tacrine

A

Reversible, indirect acting cholinoceptor agonist

Alzheimer’s balance of dopamine/ACh

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13
Q

Malathion

A

Irreversible, indirect acting cholinoceptor agonist

Treat with atropine

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14
Q

Parathion

A

Irreversible, indirect acting cholinoceptor agonist

Treat with atropine

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15
Q

Sarin

A

Irreversible, indirect acting cholinoceptor agonist

Treat with atropine

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16
Q

Echotiophate

A

Irreversible, indirect acting cholinoceptor agonist

Treat with atropine

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17
Q

Atropine

A

Blocks all muscarinic receptors

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18
Q

Ipratropium

A

M3 receptor antagonist

Used to reduce bronchial secretions in COPD/asthma

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19
Q

Benztropine

A

Cholinoceptor antagonist

CNS effects– used to balance ACh and dopa in parkinsons

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20
Q

Hexamethonium

A

Nicotinic receptor antagonist

Causes vasodilation, and anhidrosis, but o/w symp dominant effect (tachycardia etc)

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21
Q

Mecamylamine

A

Nicotinic receptor antagonist

Causes vasodilation, and anhidrosis, but o/w symp dominant effect (tachycardia etc)

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22
Q

D-tubocurarine

A

Non-depolarizing Nicotinic receptor antagonist

Inhibits Nm receptors by blocking channel

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23
Q

Succinylcholine

A

Depolarizing nicotonic receptor antagonist
Causes depolarization of Nm receptors, leading to paralysis
Used for intubation

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24
Q

Phenylepherine

A

Direct acting, Alpha 1 receptor agonist

Used to treat low BP

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25
Clonidine
Direct acting, alpha 2 receptor agonist | Decrese BP and intraocular pressure via alpha 2 receptor in ciliary epithelium
26
alpha-methadopa
Direct acting, alpha 2 receptor agonist | Decrese BP and intraocular pressure via alpha 2 receptor in ciliary epithelium
27
Apraclonidine
Direct acting, alpha 2 receptor agonist | Decrese BP and intraocular pressure via alpha 2 receptor in ciliary epithelium
28
brimonidine
Direct acting, alpha 2 receptor agonist | Decrese BP and intraocular pressure via alpha 2 receptor in ciliary epithelium
29
Metaproterenol
Direct acting Beta 2 receptor agonist | Used to treat COPD
30
Terbutaline
Direct acting, beta 2 receptor agonist | Treat COPD
31
Albuterol
Direct acting, beta 2 receptor agonist | Treat COPD, asthma
32
Ritodine
Direct acting, beta 2 receptor agonist | Causes uterine relaxation
33
Fenlodopam
Direct acting D1 receptor agonist | Increases GFR, used to treat hypertensive crises
34
Isoproterenol
Beta 1, beta 2 receptor agonist | Treat bradycardia
35
Dobutamine
beta 1, alpha 1, beta 2 receptor agonist beta 2 and alpha 1 receptors cancel out Used to increase ventricular output without increasing HR in MI
36
Epinephrine
alpha 1, alpha 2, beta 1, beta 2 receptor agonist | Used in anaphylaxis
37
Noepinephrine
alpha 1, alpha 2, beta 1 receptor agonist | Used to treat Low BP
38
Dopamine
D1, D2 alpha 1, beta 1, receptor agonist | Diuretic at low doses
39
Amphetamine
Causes release of dopaminergic vesicles | Blocked if reserpine is administered before
40
Tyramine
Increases norepinephrine synthesis
41
Prazosin
Alpha 1 receptor antagonist | Lowers BP
42
Terasosin
Alpha 1 receptor antagonist | Lowers BP
43
Doxasosin
Alpha 1 receptor antagonist | Lowers BP
44
Phenoxybezamine
Alpha 1 > alpha 2 antagonist | Used to treat phechromocytoma
45
Phentolamine
alpha 1 = alpha 2 antagonist | Given to MAOI pts who eat tyramine
46
Yohimbe
Alpha 2 > alpha 1 antagonist
47
Tamsulosin
Alpha 1a receptor antagonist | Reduce BPH symptoms
48
Labetolol
Beta blocker | Lowers BP
49
Sodium bicarbonate
Simple antacid
50
Mg(OH)2
Simple antacid
51
Al(OH)2
Simple antacid
52
Cimetidine
H2 receptor antagonist
53
Ranitidine
H2 receptor antagonist
54
Nizatidine
H2 receptor antagonist
55
Famotidine
H2 receptor antagonist
56
Omeprazole
PPI
57
Lansoprazole
PPI
58
Rabeprazole
PPI
59
Esomeprazole
PPI
60
Pantoprazole
PPI
61
Sucralfate
replaces stomach lining to heal peptic ulcers
62
Misoprostol
Stimulates PGE secretion to heal peptic ulcers
63
Bismuth subsalicylate
Coats stomach lining and increases prostaglandin synthesis to heal peptic ulcers
64
Metocloperamide
D2 receptor antagonist (antiemetic)
65
bethanechol
M3 receptor agonist | Used to increase Gi motility and bladder function
66
Neostigamine
AchE inhibitor | Used to treat abdominal distension
67
Erythromycin
Motilin receptor agonist | Induces gastroparesis
68
Methylcellulose
Bulk forming laxative
69
Glycerin
Surfactant Laxative
70
Lactulose
Osmotic laxative
71
Senna
Simulant laxative
72
Tegaserod
5Ht-4 receptor agonist | Stimulates gastroparesis
73
Lubiprostone
Prostaglandin derivative | Activates ClC2 channels to induce gastric motility
74
Methylnaltrexone
Mu-opiod receptor antagonist | Anticonstipation
75
Alvimopan
Mu-opiod receptor antagonist | Anticonstipation
76
Loperamide
Opiod receptor agonist | Induces gasteroparesis
77
Diphenoxylate
Opioid receptor agonist | Induces gasteroparesis
78
Cholestyramine
binds bile salt | Antidiarrheal
79
Octreotide
Somatostatin receptor agonist | Inhibits gasteroparesis
80
Ondansetron
5HT-3 receptor antagonist | Antiemetic
81
Scopolamine
M1 receptor antagonist | Antiemetic
82
Metocloperamide
D2 receptor antagonist | Antiemetic
83
Dimenhydrinate
H1 receptor antagonist | Antiemetic
84
Apreitant
NK1 receptor antagonist | Antiemetic
85
Prochlorperazine
M1 D2 H1 receptor antagonist
86
Lorazepam
GABA agonist | Anxiolytic/antiemetic
87
Nabilone
Cannabinoid agonist | Antiemetic
88
Dexamethasone
Glucocorticoid agonist | Antiemetic
89
Alosetron
5HT-3 receptor antagonist | Inihibits pain from IBD
90
Sulfasalazine
5ASA IBD treatment
91
Mesalamine
5-ASA | IBD treatment
92
Azathioprine
Antimetabolite | treatment for IBD
93
Methotrexate
Antimetabolite | treatment for IBD
94
Infliximan
Antibody to TNFalpha Prevents immune response in IBD
95
methotrexate
Inhibits dihydrofolate reductase, which reduces precursors for RNA and DNA synthesis
96
5FU
Incorporated into DNA and RNA | Inhibits thymidylate synthetase, which reduces DNA precursors
97
Cytaranbine (ara-c)
incorporated into DNA and RNA, which inhibits synthesis and function inhibits DNA synthesis by inhibiting DNA polymerase
98
Gemcitabine
Incorporated into DNA | Inhibits ribonucleotide reductase
99
6MP
Incorporated into DNA | Reduced precursors for RNA/DNA
100
6TG
Incorporated into DNA | Reduced precursors for RNA/DNA
101
Fludarabine
Incorporated into DNA/RNA | Inhibits DNA pol and ribonucleotide reductase
102
Cladribine
Incorporated into DNA Causes strand breaks Inhibits ribonucleotide reductase
103
Cyclophosphamide
Alkylating agent | Causes hemorrhagic cystitis via acrolein product
104
Mesna
Stops acrolein from damaging bladder during cyclophosphamide treatment
105
Carmustine (BCNU)
Alkylating agent | Brain tumors/hodgkin's
106
Cisplatin
Platinum alkylating agent Increased risk of leukemia Nephrotoxic Peripheral neuropathy
107
Carboplatin
Platinum alkylating agent Increased risk of leukemia Less toxic than cisplatin
108
Oxaliplatin
Platinum alkylating agent
109
Procarbazine
Alkylating agent for Hodgkins
110
Bacarbazine
Alkylating agent for Hodgkin's
111
Temozolomide
Alkylating agent for glioblastomas
112
Vinblastine
Inhibit microtubule assembly
113
Vincristine
Inhibits microtubule assembly | Neurological defects
114
Paclitaxel
Antimicrotubule agent | Peripheral neuropathy
115
Filgrastim (GCSF)
used with paclitaxel to reduce myelosuppression
116
Irinotecan
Topoisomerase inhibitor
117
Topotecan
Topoisomerase inhibitor
118
Etoposide
Topoisomerase inhibitor
119
Doxorubicin
Intercalates with DNA Inhibits topoisomerase II Causes irreversible cardiomyopathy
120
Dexrazoxane
Fe chelator that reduces cardiotoxicity from doxorubicin
121
Bleomycin
Chemo abx that causes DNA breaks Minimally myelosuppressive Pulmonary toxicity
122
Tamoxifen
Selective estrogen receptor modulator in treatment of breast CA
123
Anastrozole
Aromatase inhibitor | chemo for breast CA
124
Flutamide
Androgen receptor dihydrotestosterone | Used to treat prostate CA
125
Leuprolide
``` GnRH agonist (reduces testosterone) Treatment of prostate CA ```
126
Goserelin
``` GnRH agonist (reduces testosterone) Treatment of prostate CA ```
127
Degarelix
``` GnRH antagonist (reduces testosterone) Treatment of prostate CA ```
128
Trastuzumab (herceptin)
Ab against HER2 | Cardiotoxic
129
Cetuximab
Ab against EGFR | Colorectal tumors
130
Bevacizumab
Ab against VEGF Colorectal/breast CA HTN
131
Lapatinib
inhibits EGFR and HER2 kinase activity | Breast CA
132
Erlotinib
EGFR inhibitor/ATP competitive inhibitor | Small lung cell CA
133
Imatinib
Ab against BCR/ABL in CML
134
Asparaginase
N to aspartate CA cells cannot get enough N Hypersensitivity rxn
135
Bortezomib
Inhibits proteasome that degrade p53 causes peripheral neuropathy
136
Temsirolimus
``` Inhibits mTORC1 (inhibits cell cycle) Renal cell CA ```
137
Quinidine (MOA, high dose effect, adverse effects)
Class Ia antiarrhythmic Blocks Na and K channels (prolonged OT) M2 antagonist Ca blocking at high doses Cinchonism Hypotension Torsades de pointes Convert out of Afib
138
Procainamide (MOA, high dose effect, adverse effects, clinical use)
Class Ia antiarrhythmic Blocks Na and K channels (prolonged OT) Aggrevate arrhythmias SLE like symptoms Treat arrhythmias (reentry SVT, afib, aflutter)
139
Disopyramide (MOA, high dose effect, adverse effects, clinical use)
Class Ia antiarrhythmic Blocks Na and K channels (prolonged OT) Ca blocking at high doses
140
Lidocaine (MOA, adverse effects, clinical use)
Class Ib antiarrhythmic Blocks Na channels (lowers Vmax) tinnitus, Szs Digitalis induced arrhythmias. second line for ventricular arrhythmias
141
Propafenone (MOA, clinical use, adverse effects)
Class Ic antiarrhythmic Blocks Na channels Beta blocker Treats atrial arrhythmias Lower LV
142
Flecainide (MOA, clinical use, adverse effects)
Class Ic antiarrhythmic Blocks Na channels Slows intraventricular conduction Can cause fatal arrhythmias
143
Amiodarone (MOA, clinical use, adverse effects)
Class III antiarrhythmic Blocks Ca, Na, K, and beta receptors Prolongs phase 3 repolarization (increase QT). Acute termination of VT of VF Lethal pneumonitis Hypotension
144
Dronedarone (MOA, clinical use, adverse effects)
Class III antiarrhythmic Blocks Ca, Na, K, and beta receptors Prolongs phase 3 repolarization (increase QT). Acute termination of VT of VF Lethal pneumonitis Hypotension
145
Sotalol (MOA, clinical use, adverse effects)
Class III antiarrhythmic Blocks Ca, Na, K, and beta receptors Prolongs phase 3 repolarization (increase QT). Acute termination of VT of VF Lethal pneumonitis Hypotension
146
Ibutilide (MOA, clinical use, adverse effects)
Class III antiarrhythmic Blocks Ca, Na, K, and beta receptors Prolongs phase 3 repolarization (increase QT). Acute termination of VT of VF Lethal pneumonitis Hypotension
147
Dofetilide (MOA, clinical use, adverse effects)
Class III antiarrhythmic Blocks Ca, Na, K, and beta receptors Prolongs phase 3 repolarization (increase QT). Acute termination of VT of VF Lethal pneumonitis Hypotension
148
Verapamil
Class IV antiarrhythmic Ca channel blocker (NDHP) Depresses SA node automaticity Used to control supraventricular tachycarida
149
Diltiazem
Class IV antiarrhythmic Ca channel blocker (NDHP) that works equally in the heart and the vasculature Depresses SA node automaticity
150
Nifedipine
Class IV Ca channel blocker (DHP) that works mainly in the vasculature
151
Adenosine
Antiarrhythmic Activates A1 receptors on heart to hyperpolarize SA cells with K A2 receptors in vasculature increase NO production Used for treating SVT d/t re entry pathways
152
Carbonic anhydrase inhibitors
Inhibit CA in the renal cells, causing increased HCO3 and water excretion. Can cause metabolic acidosis and renal stones
153
Mannitol
Osmotic diuretic Treats cerebral edema Can cause hypokalemia d/t increased [solute] at end ot DCT
154
Glycerin
Osmotic diuretic Treats cerebral edema Can cause hypokalemia d/t increased [solute] at end ot DCT
155
Isosorbide
Osmotic diuretic Treats cerebral edema Can cause hypokalemia d/t increased [solute] at end ot DCT
156
Urea
Osmotic diuretic Treats cerebral edema Can cause hypokalemia d/t increased [solute] at end ot DCT Should not be given to cirrhotic pts
157
Furosemide
``` Loop diuretic (inhibits Na/K/Cl cotransporter) Causes vasodilation ``` Causes Ca, Mg, K loss

Pharm (73 decks)

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