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Things I don't know, test 2 Flashcards

1
Q

Filgrastim is given with what CA drug to reduce myelosuppression?

A

Pacltaxel

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2
Q

What is the mechanism by which cell acquire resistance to cyclophosphamide?

A

Increase glutathione
Increase DNA repair
Increase MGMT enzyme to remove alkyl groups

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3
Q

What is the mechanism by which cell acquire resistance to cetuximab?

A

RAS pathway mutation

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4
Q

What is the cancer that cytarabine is used to treat?

A

AML

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5
Q

What is the cancer that fludarabine is used to treat?

A

CLL

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6
Q

What is the cancer that temsirolimus is used to treat?

A

Renal cell CA

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7
Q

What is the cancer that bortezomib is used to treat?

A

Multiple myeloma

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8
Q

What is the MOA of argatroban?

A

direct thrombin inhibitor

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9
Q

What is the MOA of apixaban?

A

factor X inhibitor

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10
Q

What is the MOA of bivalirudin?

A

Bivalent thrombin inhibitor

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11
Q

What is the MOA of dabigatran?

A

Direct thrombin inhibitor

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12
Q

What is the MOA of lepirudin?

A

Bivalent thrombin inhibitor

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13
Q

What is the MOA of fondaparinux?

A

Synthetic heparin that can only inhibit thrombin

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14
Q

What is the MOA of vorapaxar?

A

PPARalpha inhibitor on platelets

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15
Q

What is the MOA of prasugrel?

A

Irreversible P2Y12 inhibitor on platelets

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16
Q

What is the MOA of clopidogrel?

A

Irreversible P2Y12 inhibitor on platelets

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17
Q

What is the MOA of ticagrelor?

A

Reversible P2Y12 inhibitor (given in active form)

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18
Q

What is the MOA of cangrelor?

A

Reversible P2Y12 inhibitor (given IV)

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19
Q

What are the specific drugs that inhibit warfarin?

A

Rifampin

Barbiturates

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20
Q

What are the two drugs that inhibit tPA?

A

Aminocaproic acid

Tranexamic acid

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21
Q

What is the cause of primary chylomicronemia?

A

Decreased LPL activity

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22
Q

What is the cause of familial hypertriglyceridemia?

A

impaired VLDL removal

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23
Q

What is the cause of familial combined hyperlipoproteinemia?

A

Increased VLDL production

24
Q

What is the cause of Familial dysbetalipoproteinemia?

A

Decreased clearance of VLDL, IDL, and chylomicrons

25
What is the cause of familial hypercholesterolemia?
LDL receptor impairments
26
What is the cause of familial ligand-defective apoB?
Mutation in apoB100, impaired LDL uptake
27
What are the diseases that nitrates are useful for treating?
All hypercholesterolemia and triglyceridemia
28
What is the MOA of fondaparinux?
Synthetic heparin that binds to antithrombin and increases the rate of factor X inhibition
29
What is the MOA of Lepirudin?
DTI (binds to fibrin binding site, and active site)
30
What is the MOA of bivalirudin?
DTI (binds to fibrin binding site, and active site)
31
What is the MOA of argatroban?
DTI (binds to fibrin binding site, and active site)
32
What is the MOA of dabigatran?
DTI (binds to fibrin binding site, and active site)
33
What is the MOA of apixaban?
factor X inhibitor
34
What is the MOA of rivaroxaban?
Factor X inhibitor
35
What are the two drugs that inhibit tPA?
Aminocaproic acid | Tranexamic acid
36
What is the MOA of furosemide?
Loop diuretic
37
What is the MOA of bumetanide?
Loop diuretic
38
What is the MOA of Ethacrynic acid?
Loop diuretic
39
What is the first line drug for HTN with DM? Add-on therapy?
ACEI or ARB Thiazide, then Beta blocker or CCB
40
What is the first line drug for HTN with CKD?
ACEI or ARB
41
What is the first line drug for HTN with CAD? Add-on therapy?
beta blocker with ACEI/ARB Aldosterone antagonist, CCB, or thiazide
42
What is the first line drug for HTN with LVD? Add-on therapy?
Diuretic + ACEI/ARB + beta blocker Aldosterone antatongist or thiazide
43
What is the first line drug for HTN with previous ischemic stroke?
ACEI wwo thiazide
44
What is the MOA of furosemide?
Loop diuretic
45
What is the MOA of butanide?
Loop diuretic
46
What is the MOA of amiloride?
Renal epithelial Na channel inhibitor
47
What is the MOA of acetazolamide?
CA inhibitor
48
What is the MOA of metolazone?
Thiazide diuretic
49
What is the MOA of indapamide?
thiazide diuretic
50
What is the MA of triamterene?
Renal epithelial Na channel inhibitor
51
How do you treat decreased LPL function? (Chylomicronemia)
Fibrates and niacin
52
How do you treat decrease apoE function?
Fibrates and niacin
53
How do you treat decrease apo CII function/expression? (dys
Fibrates and niacin
54
How do you treat LDL receptor function? (familial hypercholesterolemia)
Statins Ezetimibe Resins Niacin
55
How do you treat decrease apo B100? (familial dysbetalipoproteinemia)
Statins Ezetimibe Resins Niacin

Pharm (73 decks)

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