Flashcards in Bichem terms flash Deck (40)
Binds to site distinct from substrate binding site to induce conformational change which reduces enzyme activity. Decreased Vmax.
Insulin binds 2 alpha domains. 2 beta domains contain tyrosine kinase activtity and are transmembrane to interior. Insulin receptor autophosphorylates and IRS-1 binds and is phosphorylated on tyrosine.
No intrinsic kinase activity, linked to G protein (G protein coupled receptor), similar to epinephrine. Undergoes conformational change when bound that transmits signal to G protein
Heterotrimeric. Alpha binds GDP/GTP. Gi (inhibitory protein), Gs (stimulatory protein)
Stronger oxidizing than NAD+. Flavin, d-ribitol, pyrophosphate, ribose, adenine. Accepts 1 electron at a time
Derived from pantothenic acid. Provides active sulfhydral
5 member ring with disulfide bond. Arsenite interferes with sulfhydral groups
RQ = CO2 produced/ O2 consumed. For carbs = 1
Muscle fibers, type 1
Slow twitch, many mito., aerobic metabolism, resistant to fatigue