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Flashcards in Bichem terms flash Deck (40)
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31

Non-competitive inhibitor

Binds to site distinct from substrate binding site to induce conformational change which reduces enzyme activity. Decreased Vmax.

32

Insulin receptor

Insulin binds 2 alpha domains. 2 beta domains contain tyrosine kinase activtity and are transmembrane to interior. Insulin receptor autophosphorylates and IRS-1 binds and is phosphorylated on tyrosine.

33

Glucagon receptor

No intrinsic kinase activity, linked to G protein (G protein coupled receptor), similar to epinephrine. Undergoes conformational change when bound that transmits signal to G protein

34

G protein

Heterotrimeric. Alpha binds GDP/GTP. Gi (inhibitory protein), Gs (stimulatory protein)

35

FAD

Stronger oxidizing than NAD+. Flavin, d-ribitol, pyrophosphate, ribose, adenine. Accepts 1 electron at a time

36

Coenzyme A

Derived from pantothenic acid. Provides active sulfhydral

37

Lipoic acid

5 member ring with disulfide bond. Arsenite interferes with sulfhydral groups

38

Respiratory Quotient

RQ = CO2 produced/ O2 consumed. For carbs = 1

39

Muscle fibers, type 1

Slow twitch, many mito., aerobic metabolism, resistant to fatigue

40

Muscle fibers, type 2

Fast twitch, few mito., anaerobic metabolism, prone to fatigue