‼️BIOCHEM-Special Topics Flashcards Preview

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Flashcards in ‼️BIOCHEM-Special Topics Deck (28):
1

Examples of acidic sugars

Glucuronic acid
Iduronic acid

2

GAG in mast cells

Heparin

3

All GAGs are attached to proteins to form

Proteoglycans

4

GAG located at sites of calcification in endochondral bone and are also found in cartilage

Chondroitin sulfate

5

GAGs that play a role in corneal transparency

Keratan sulfate I and dermatan sulfate

6

GAG Structural role in sclera

Dermatan sulfate

7

Heparin binds with factors

IX and XI

8

GAG that determines the charge selectiveness of renal glomerulus

Heparan sulfate

9

Synthesis of GAGs occur in which organelles?

ER and golgi apparatus

10

How are GAGs degraded?

They are phagocytosed and vesicles fuse with lysosomes where they are degraded

11

Lysosomal degradationof GAGs are accomplished by

Acid hydrolases

12

Accumulation of GAGs in lysosomes due to deficiency in hydrolases

Mucopolysaccharidoses

13

All mucopolysaccharidoses are autosomal recessive except for

Hunter's syndrome (x-linked recessive)

14

All mucopolysaccharidoses have mental retardation except

Morquio's syndrome

No CNS involvement

15

Mucopolysaccharidoseses with deficiency in alpha L iduronidase

Hurler's and Scheie's syndrome

16

Type VII mucopolysaccharidoses
Enzyme deficiency?

Sly syndrome
Beta glucoronidase

17

Type II mucopolysaccharidoses
Enzyme deficient?

Hunter's syndrome

Iduronate sulfatase

18

Type III mucopolysaccharidoses

Sanfilippo syndrome

19

Morquio's syndrome is deficient in

Galactose 6 sulfatase

20

Proteins to which oligosaccharides are covalently attached

Glycoproteins

21

Length of carbohydrate chain in gycoprotein is relatively

Vs proteoglycans

Short and branched

Proteoglycans: linear and longer

22

Sugar units in glycoproteins vs proteoglycans

GP - NO repeating sugar units

PG- WITH repeating sugar units

23

Major classes of glycoproteins

O- linked
N-linked
GPI-linked

24

O-linked glycoproteins are bound to which amino acids

Serine and threonine

25

N-linked glycoproteins are bound to what amino acid?

Asparagine

26

Production of O-linked vs N-linked Glycoprotein

O-linked gOlgi apparatus
N-linked eNdoplasmic ret

27

R group

O-linked vs N-linked

o- hydroxyl
n- amide

28

Glycosaminoglycans are generally composed of

Repeating disaccharide units

Amino sugar
Acidic sugar