⭐️ BIOCHEMISTRY Flashcards Preview

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Flashcards in ⭐️ BIOCHEMISTRY Deck (16):
0

Most common chemical component of living organisms

Water

1

Structure of the water molecule

Slightly skewed tetrahedron

2

The body weight of a normal person consists of

40% dry weight
60% water

3

60% water in the human body is subdivided into

2/3 40%intracellular
1/3 20%extracellular

4

Of the 20% (of body weight) extracellular water in the body, how many percent is interstitial fluid and plasma?

15% interstitial fluid
5% plasma

5

What is a dipole?

A molecule woth electrical charge distributed asymmetrically about its structure.

6

Water has a high dielectric constant. What does this mean?

Water greatly increases the force of attraction between charged and polar species.

7

Explain.

Water is an excellent nucleophile.

Nucleophilic attack by water generally results in the cleavage of the amide, glycoside, or ester bonds that hold bipolymers together.

In other words, water breaks polymers together hence it is a good solvent.

8

Explain.

Water is amphoteric.

It can dissciate into hydronium and hydroxide ions. It is both an acid and a base.

9

Amphoteric vs amphipathic

Amphoteric- can act as both an acid and a base
Ampipathic- has hydrophilic and hydrophobic parts

10

Measure of acidity or alkalinity

pH

11

pH is defined as

-log [H+]

12

What is the normal pH of blood?

7.35-7.45

14

Acids vs bases

Acids are proton donors
Bases are proton acceptors

15

Enzyme most likely involved in lens opacities in DM

Aldose reductase

16

Amino acid deficient in PKU

Tyrosine