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Flashcards in Biochemistry Thyroid Deck (55)
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1

Thyroid Hormone

T3 is 5x more active as T4

2

T4 secretion

T3 secretion

3

T3 secretion

<20% secreted from thyroid, majority from peripheral de-iodination of T4.

4

3 proteins which bind thyroid hormone

Thyroid binding globulin (TBG)
Thyroid binding pre-albumin
Albumin

5

Bound T4 proportions

• 99.98% of T4 is bound (70% TB, 20% TBPA, - 10% Alb
• 99.7% T3 is bound
• Only the free forms (unbound are active)

6

Patient 1: serum results
T.S.H 60.0
Free T4 4.4
Free T3 ---
Clinical information: tired, weight gain

Diagnosis

1o hypothyroidism – impaired T4 production and loss of negative feedback

7

Primary Hypothyroidism: Biochemical Features

Raised TSH
Low Ft4
Ft3 – not helpful

8

Primary Hypothyroidism:Clinical Features

Lethargy, tiredness
Weight gain
Cold intolerance
Coarsening of hair and skin
Slow reflexes, hoarseness
Constipation
Menstrual abnormalities
Bradycardia

9

Patient 2 →
T.S.H -10.0 (abnormal)
Free T4 – 13.2 (decreased slightly but not abnormal)
Free T3 ---
Clinical Information
Cold intolerance, constipation
Diagnosis

Compensated Hypothyroidism

10

Compensated Hypothyroidism: Biochemical Features

Raised TSH (4-15 min/L)
Low normal FT4
+ve Anti-thyroid peroxidase antibodies

11

Compensated Hypothyroidism: Wickham study

Management of this form of hypothyroidism is looking at the annual risk of overt hypothyroidism of TSH >6.0min/L and or TPOAb positive – thyroxine guidelines → TSH +10 even if T4 is low/normal.

12

Patient 3 →
T.S.H – 10
Free T4 ---
Free T3 ---
Clinical information: On Thyroxine
Diagnosis

This patient requires increased dose to suppress TSH

13

Thyroxin Replacement → Aiming for levels of T.S.H and FT4 of
Ideal – adequate replacement

T.S.H – 2.0 (0.3-4.0)
Free T4 of 16.8 (10.0-24.0)

14

Thyroxin Replacement → Inadequate replacement – low dose or poor compliance

T.S.H – 20.0
Free T4 – 5.0

15

Thyroxin Replacement → Irregular compliance or recent change in dose (need to be on stable dose for 6 weeks)

T.S.H 12.0
Free T4 16.8

→ Under replaced but normal = adequate therefore need to take results after 6 weeks

16

Thyroxin Replacement → Adequate/over replacement increased risk AF (not normal to measure FT3)

T.S.H <0.02 (suppressed)
Free T4 – 23.0
Free T3 – 3.0

17

Thyroxin Replacement →Over replacement

T.S.H <0.02
Free T4 34.0
Free T 3 ---

18

Thyroxin Replacement → Special situations

Patients with thyroid cancer on thyroxine
Some patients may be given T3 (deliberately supress TSH)

19

Thyroxin Replacement → Using T3 for replacement is difficult because

• More potent
• Increased risk
• T0.5 shorter therefore management and dosing difficult

20

Patient 4 →
T.S.H <0.02
Free T4 50.2
Free T3 22.0
Clinical Information: Weight loss, palpitations

Diagnosis

Thyrotoxicosis

21

Primary Hyper-thryoidism: Biochemical Features

Undetectable TSH
Raised FT4
Raised Ft3

22

Primary Hyper-thryoidism: Clinical Features

Weight los
Heat intolerance
Palpitations
Agitation, tremor
Muscle Weakness
Diarrhoea
Thyroid eye disease
Menstrual abnormalities

23

Best discrimination of hyperthyroidism

FT3 then FT4

24

T3 toxicoisis serum levels

T.S.H <0.02
Free T4 23.0
Free T3 12.0

25

T3 toxicoisis diagnosis requires

Need FT3 measurement in patients with high normal – slight increased FT4

26

Not Clear thyrotoxicosis

T.S.H <0.02 (low)
Free T3 23.0 (normal/high)
Free T4 6.8 (normal)

27

Not Clear thyrotoxicosis management

Recheck in recouple of months to confirm
Remains suppressed (due to risks) then therefore confirm anti-thyroid treatment but evidence not 100% clear.

28

Effects of non-thyroidal illness→

• Common in hospitalised patients
• Occurs in a variety of pathological conditions
• Pattern of results
o TSH low (may be increased in recovery phase)
o FT4/FT3 low or normal – metabolic response to illness
o Increased reverse T3 – metabolically inactive

→ Basal metabolism slowed down to protect body from illness.

29

Causes of TSH suppression

• TNF
• IL-1
• Low TRH
• Somatostatin
• Glucocorticoids
Dopamine

30

Amiodarone

→ hypo and hyperthyroidism (contains lots of iodine → long half-life (weeks) therefore can stop and wait to identify if its drug induced or has hypo/hyper primary.

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