Seminar G Polyarteritis Nodosa Flashcards Preview

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Flashcards in Seminar G Polyarteritis Nodosa Deck (5)
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1

Definition

A rare systemic illness characterised by necrotising inflammation of medium-sized arteries leading to aneurysm formation.
Principally affects viscera, and may lead to organ infarction if left untreated

2

Clinical Features

Fever
Weight loss
Malaise
GI upset
Vasculitic rash
Renal, pulmonary and CVS involvement may also occur
Peripheral neuropathy may also occu, due to involvement of the vasa nervorum

3

Association with

HEP B infection

4

Clinical diagnosis may be confirmed either by

Histological analysis of affected organs
Coeliac axis or renal arteriograms (beading pattern of microaneurysms)

5

Treatment →

High-dose glucocorticoids usually with pulsed cyclophosphamide therapy

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