Seminar G - Connective Tissue Disease Flashcards Preview

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Flashcards in Seminar G - Connective Tissue Disease Deck (10):
1

Definition


A heterogeneous group of non-organ specific autoimmune diseases.

→Collagen Vascular diseases, they are distinct form the true diseases of collagen such as Marfan’s Syndrome and Ehlers-Danlos Syndrome.

2

Ehlers-Danlos Syndrome

Defect in the production, structure or processing of collagen.

3

Organ Specific autoimmune disease

Type 1 Diabetes Mellitus
Addison’s Disease
Hasimoto’s Thyroiditis
Pernicious Anaemia

4

Non-organ Specific autoimmune disease

RA
SLE
Sjogrens Syndrome
Polymyositis

5

Livedo reticularis

• Livedo reticularis (trunk, arms and legs) – netlike
pattern of reddish-blue skin discoloration
• Idiopathic

6

Henoch-Schonlein purpura

• Generally occurs over the buttocks
• Any ulceration should be inspected and bipopsied for signs of cutaneous vasculitis

7

Blood tests



Inflammatory markers
• Raised ESR
• Raised plasma viscosity
• C-reactive protein
• RF
• Autoimmune profile (Antinuclear antibodies, antibodies to dsDNA)
• Urea and electrolytes
• Liver function tests
• Bone profile (Calcium, phosphate etc)
• Thyroid function tests

8

Additional Tests

Serum electrophoresis (with urine for Bence-Jones protein)
Complement (C3, C4) levels
Cryoglobulines
Creatine Kinase
Serum urate
HLA typing

9

X-ray

Pulmonary Fibrosis in SLE and RA
→Opacity especially in the mid, and lower zones on the right lung

10

Other tests

Spirometry (+/- full pulmonary function tests)
Chest radiograph
Echocardiagram
Barium Swallow
Electromyogram
Muscle biopsy

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