Seminar G - Connective Tissue Disease Flashcards Preview

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Flashcards in Seminar G - Connective Tissue Disease Deck (10)
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1
Q

Definition

A

A heterogeneous group of non-organ specific autoimmune diseases.

→Collagen Vascular diseases, they are distinct form the true diseases of collagen such as Marfan’s Syndrome and Ehlers-Danlos Syndrome.

2
Q

Ehlers-Danlos Syndrome

A

Defect in the production, structure or processing of collagen.

3
Q

Organ Specific autoimmune disease

A

Type 1 Diabetes Mellitus
Addison’s Disease
Hasimoto’s Thyroiditis
Pernicious Anaemia

4
Q

Non-organ Specific autoimmune disease

A

RA
SLE
Sjogrens Syndrome
Polymyositis

5
Q

Livedo reticularis

A

• Livedo reticularis (trunk, arms and legs) – netlike
pattern of reddish-blue skin discoloration
• Idiopathic

6
Q

Henoch-Schonlein purpura

A
  • Generally occurs over the buttocks

* Any ulceration should be inspected and bipopsied for signs of cutaneous vasculitis

7
Q

Blood tests

A
Inflammatory markers
•	Raised ESR
•	Raised plasma viscosity
•	C-reactive protein
•	RF
•	Autoimmune profile (Antinuclear antibodies, antibodies to dsDNA)
•	Urea and electrolytes
•	Liver function tests
•	Bone profile (Calcium, phosphate etc)
•	Thyroid function tests
8
Q

Additional Tests

A
Serum electrophoresis (with urine for Bence-Jones protein)
Complement (C3, C4) levels
Cryoglobulines
Creatine Kinase
Serum urate
HLA typing
9
Q

X-ray

A

Pulmonary Fibrosis in SLE and RA

→Opacity especially in the mid, and lower zones on the right lung

10
Q

Other tests

A
Spirometry (+/- full pulmonary function tests)
Chest radiograph
Echocardiagram
Barium Swallow
Electromyogram
Muscle biopsy

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