FN: Anti-phospholipid Syndrome Flashcards Preview

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Flashcards in FN: Anti-phospholipid Syndrome Deck (11)
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1
Q

Classificatoin

A

Primary: 70%

Secondary to SLE: 30%

2
Q

Pathology

A

Anti-phospholipid Abs: anti-cardiolipin and lupus anticoagulant

3
Q

Features

A
  1. CLOTS: venous (e.g. DVT) and arterial (e.g. stroke)
  2. Coagulation defect: increase APTT
  3. Livido reticularis
  4. Obstetric complications: recurrent 1st trimester abortion
  5. Thrombocytopaenia
4
Q

Treatment

A

Low dose aspirin

Warfarin if recurrent thrombosis: INR 3.5

5
Q

Management

A

in specialist SLE and lupus nephritis clinics

6
Q

Sever flares: Acute SLE

A

AIHA, nephritis, pericarditis or CNS disease

High-dose prednisolone and IV cyclophosphamide

7
Q

Cutaneous symptoms

A

Treat with topical steroids and prevent with sun cream

8
Q

Maintenance

A

For joint and skin symptoms

NSAIDS and hydroxychloroquine and lose dose steroids

9
Q

Lupus Nephritis

A

Proteinuria:ACEi

Aggressive GN: immunosuppression

10
Q

Treatment complications

A

Increased risk of osteoporosis and CV disease

11
Q

Prognosis

A

80% survival @ 15 yrs

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