FN: Anti-phospholipid Syndrome Flashcards Preview

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Flashcards in FN: Anti-phospholipid Syndrome Deck (11):
1

Classificatoin

Primary: 70%
Secondary to SLE: 30%

2

Pathology

Anti-phospholipid Abs: anti-cardiolipin and lupus anticoagulant

3

Features

1. CLOTS: venous (e.g. DVT) and arterial (e.g. stroke)
2. Coagulation defect: increase APTT
3. Livido reticularis
4. Obstetric complications: recurrent 1st trimester abortion
5. Thrombocytopaenia

4

Treatment

Low dose aspirin
Warfarin if recurrent thrombosis: INR 3.5

5

Management

in specialist SLE and lupus nephritis clinics

6

Sever flares: Acute SLE

AIHA, nephritis, pericarditis or CNS disease

High-dose prednisolone and IV cyclophosphamide

7

Cutaneous symptoms

Treat with topical steroids and prevent with sun cream

8

Maintenance

For joint and skin symptoms
NSAIDS and hydroxychloroquine and lose dose steroids

9

Lupus Nephritis

Proteinuria:ACEi
Aggressive GN: immunosuppression

10

Treatment complications

Increased risk of osteoporosis and CV disease

11

Prognosis

80% survival @ 15 yrs

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